Evidence map›Paper›PMID 28533372›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Visualization and characterization of individual type III protein secretion machines in live bacteria.

Yongdeng Zhang, María Lara-Tejero, Jörg Bewersdorf, Jorge E Galán

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Case Study: Illuminating the Nanoscale World of Microbiology.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Experimental Approaches to Visualize Effector Protein Translocation During Host-Pathogen Interactions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Assembly and architecture of the type III secretion sorting platform.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Article
  17. Article
  18. Endomembrane remodeling and dynamics inMicrobial cell (Graz, Austria) · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yongdeng ZhangDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520.ORCID 0000-0002-4569-8137
María Lara-TejeroDepartment of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, CT 06536.
Jörg BewersdorfDepartment of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520; jorge.galan@yale.edu joerg.bewersdorf@yale.edu.
Jorge E GalánDepartment of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, CT 06536; jorge.galan@yale.edu joerg.bewersdorf@yale.edu.
Yale University · US

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Richard A Flavell · 1993 to 2026
$44.0M
MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASIONR37AI030492 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2000 to 2024
$10.1M
MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASIONR01AI030492 · NIAID · YALE UNIVERSITY · PI Jorge E Galan · 1995 to 2026
$3.1M
NIAID NIH HHS R01 AI030492NIAID NIH HHS R37 AI030492NIDDK NIH HHS P30 DK045735Wellcome Trust 095927/A/11/ZWellcome Trust 203285/Z/16/Z
6 · The paper itself

Abstract

Type III protein secretion machines have evolved to deliver bacterially encoded effector proteins into eukaryotic cells. Although electron microscopy has provided a detailed view of these machines in isolation or fixed samples, little is known about their organization in live bacteria. Here we report the visualization and characterization of the

Indexed as

BacteriaBacterial ProteinsBacterial Secretion SystemsCluster AnalysisModels, MolecularProtein TransportSalmonella typhimuriumSingle Molecule ImagingType III Secretion SystemsBacterial ProteinsBacterial Secretion SystemsType III Secretion Systemsbacterial nanomachinesbacterial pathogenesisprotein secretionSalmonella virulencesuperresolution microscopy

Identifiers

PMID28533372
PMCPMC5468683
OpenAlexW2618701693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.