ArticleEndocrine-related cancer2017
Loss-of-function mutations in the
Open access · hybridAbstract read
In one paragraph
Article in Endocrine-related cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 1, general recommendations.Nature reviews. Endocrinology · 2024Guideline
- The germline landscape of pituitary adenomas: established and emerging predisposition genes.The Journal of clinical endocrinology and metabolism · 2026Review
- The genetics of hypertension.Nature reviews. Nephrology · 2026Review
- Overlapping Presentations and Diverse Genetic Defects Characterize Neuroendocrine Neoplasms in a Mexican Cohort.The Journal of clinical endocrinology and metabolism · 2025Article
- Clinical Implications of Molecular and Genetic Biomarkers in Cushing's Disease: A Literature Review.Journal of clinical medicine · 2025Review
- Clinical implications and molecular mechanism of long noncoding RNA LINC00518 and protein-coding genes in skin cutaneous melanoma by genome‑wide investigation.Archives of dermatological research · 2025Article
- Cushing syndrome.Nature reviews. Disease primers · 2025Review
- Refractory corticotroph adenomas.Pituitary · 2023Review
- Pituitary Tumorigenesis-Implications for Management.Medicina (Kaunas, Lithuania) · 2023Review
- The hallmarks of cancer… in pituitary tumors?Reviews in endocrine & metabolic disorders · 2023Review
- Germline loss-of-functionmedRxiv : the preprint server for health sciences · 2023Article
- Review
- Gene Mutations in Cushing's Syndrome.Molecular syndromology · 2023Review
- Germline loss-of-functionFrontiers in endocrinology · 2023Article
- Genetic drivers of Cushing's disease: Frequency and associated phenotypes.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Article
- Review
- Molecular Derangements and the Diagnosis of ACTH-Dependent Cushing's Syndrome.Endocrine reviews · 2022Review
- Aggressive corticotroph tumors and carcinomas.Journal of neuroendocrinology · 2022Review
- Genetic Basis of ACTH-Secreting Adenomas.International journal of molecular sciences · 2022Review
- [Update on mechanisms of pituitary tumorigenesis.]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 11 institutions in 5 countries.
Laura C Hernández-RamírezSection on Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Ryhem GamLaboratoire de Génétique MoléculaireInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada.
Nuria ValdésSection on Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Maya B LodishSection on Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Nathan PankratzDepartment of Laboratory Medicine and PathologyUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA.
Aurelio BalsalobreLaboratoire de Génétique MoléculaireInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada.
Yves GauthierLaboratoire de Génétique MoléculaireInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada.
Fabio R FauczSection on Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Giampaolo TrivellinSection on Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Prashant ChittiboinaSurgical Neurology BranchNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
John LaneDepartment of Laboratory Medicine and PathologyUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA.
Denise M KayNewborn Screening ProgramWadsworth Center, New York State Department of Health, Albany, New York, USA.
Aggeliki DimopoulosDivision of Intramural Population Health ResearchEpidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Stephan GaillardInstitut CochinINSERM U1016, CNRS UMR8104, Université Paris Descartes, Paris, France.
Mario NeouInstitut CochinINSERM U1016, CNRS UMR8104, Université Paris Descartes, Paris, France.
Jérôme BertheratInstitut CochinINSERM U1016, CNRS UMR8104, Université Paris Descartes, Paris, France.
Guillaume AssiéInstitut CochinINSERM U1016, CNRS UMR8104, Université Paris Descartes, Paris, France.
Chiara VillaInstitut CochinINSERM U1016, CNRS UMR8104, Université Paris Descartes, Paris, France.
James L MillsDivision of Intramural Population Health ResearchEpidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Jacques DrouinLaboratoire de Génétique MoléculaireInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada.
Constantine A StratakisSection on Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA stratakc@mail.nih.gov.
Montreal Clinical Research Institute · CANational Institutes of Health · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USInserm · FRUniversity of Minnesota Medical Center · USAssistance Publique – Hôpitaux de Paris · FRHôpital Cochin · FRNational Institute of Neurological Disorders and Stroke · USNew York State Department of Health · USUniversidad de Oviedo · ESUniversity of Liège · BE
Funding
Molecular Genetics of Endocrine Tumors and Related DisordersZIAHD008920 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 2012 to 2021
$25.8MImproved Diagnosis and Treatment of Cushing's DiseaseZIANS003150 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI CHITTIBOINA, PRASHANT · 2015 to 2025
$13.7MCushing's Disease Whole Exome Sequencing StudyZIAHD008939 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MILLS, JAMES · 2014 to 2023
$1.2MCIHR
Abstract
The
Indexed as
AdenomaAdolescentAdultAnimalsCarrier ProteinsCell Line, TumorChildCyclinsDNA Copy Number VariationsFemaleHumansMaleMiceMutationPhosphoproteinsPituitary ACTH HypersecretionCABLES1 protein, humanCarrier ProteinsCyclinsPhosphoproteinscorticotropinomaCushing’s diseasegermline mutationwhole-exome sequencing
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.