ArticleHypertension (Dallas, Tex. : 1979)2017
PGC-1α (Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure.
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Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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39citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Metabolic Syndrome in an Aging Society - Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis.Clinical interventions in aging · 2021Pooled it
- Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026Review
- Autophagy modulates the mechanism of flow-mediated dilation upstream of telomerase.Basic research in cardiology · 2025Article
- Characterization of anticancer therapy-induced microvascular dysfunction in patients with breast cancer supports targeted intervention.JCI insight · 2025Article
- Endothelial TERT drives microvascular phenotype associated with coronary artery disease.American journal of physiology. Heart and circulatory physiology · 2025Article
- Impaired endothelial function contributes to cardiac dysfunction: role of mitochondrial dynamics.American journal of physiology. Heart and circulatory physiology · 2025Review
- Peroxisome proliferator‑activated receptor γ coactivator‑1α in heart disease (Review).Molecular medicine reports · 2025Review
- Is the peripheral microcirculation a window into the human coronary microvasculature?Journal of molecular and cellular cardiology · 2024Review
- Vascular Response of Triiodothyronine on Isolated Aortic Rings: Contribution of Redox Mechanisms.Arquivos brasileiros de cardiologia · 2024Article
- The Impact of Flow-Mediated Vasodilatation on Mechanism and Prognosis in Patients with Acute Coronary Syndrome: A FMD and OCT Study.Reviews in cardiovascular medicine · 2024Article
- Necessary Role of Ceramides in the Human Microvascular Endothelium During Health and Disease.Circulation research · 2024Article
- Lipid phosphate phosphatase 3 maintains NO-mediated flow-mediated dilatation in human adipose resistance arterioles.The Journal of physiology · 2023Article
- Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stress.American journal of physiology. Heart and circulatory physiology · 2022Review
- S1P (Sphingosine-1-Phosphate)-Induced Vasodilation in Human Resistance Arterioles During Health and Disease.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Role of Adiponectin Receptor 1 in Promoting Nitric Oxide-Mediated Flow-Induced Dilation in the Human Microvasculature.Frontiers in pharmacology · 2022Article
- Noncanonical Role of Telomerase in Regulation of Microvascular Redox Environment With Implications for Coronary Artery Disease.Function (Oxford, England) · 2022Article
- PGC-1α gene transfer restores adhesion and reendothelialization of endothelial progenitor cells from patients with hypertension.Journal of human hypertension · 2021Article
- Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases.American journal of physiology. Heart and circulatory physiology · 2021Review
- Sweat the small stuff: The human microvasculature and heart disease.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Article
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Authors and funding
9 authors at 1 institution in 1 country.
Andrew O KadlecFrom the Department of Physiology (A.O.K., A.M.B., D.D.G.), Division of Cardiology, Department of Medicine (D.S.C., K.A.-A., J.C.H., A.M.B., D.D.G.), Cardiovascular Center (A.O.K., D.S.C., K.A.-A., J.C.H., M.J.D., J.K.F., A.M.B., D.D.G.), Department of Physical Medicine and Rehabilitation (M.J.D.), Division of Colorectal Surgery, Department of Surgery (M.F.O.), and Department of Anesthesiology (J.K.F.), Medical College of Wisconsin, Milwaukee.
Dawid S ChabowskiFrom the Department of Physiology (A.O.K., A.M.B., D.D.G.), Division of Cardiology, Department of Medicine (D.S.C., K.A.-A., J.C.H., A.M.B., D.D.G.), Cardiovascular Center (A.O.K., D.S.C., K.A.-A., J.C.H., M.J.D., J.K.F., A.M.B., D.D.G.), Department of Physical Medicine and Rehabilitation (M.J.D.), Division of Colorectal Surgery, Department of Surgery (M.F.O.), and Department of Anesthesiology (J.K.F.), Medical College of Wisconsin, Milwaukee.
Karima Ait-AissaFrom the Department of Physiology (A.O.K., A.M.B., D.D.G.), Division of Cardiology, Department of Medicine (D.S.C., K.A.-A., J.C.H., A.M.B., D.D.G.), Cardiovascular Center (A.O.K., D.S.C., K.A.-A., J.C.H., M.J.D., J.K.F., A.M.B., D.D.G.), Department of Physical Medicine and Rehabilitation (M.J.D.), Division of Colorectal Surgery, Department of Surgery (M.F.O.), and Department of Anesthesiology (J.K.F.), Medical College of Wisconsin, Milwaukee.
Joseph C HockenberryFrom the Department of Physiology (A.O.K., A.M.B., D.D.G.), Division of Cardiology, Department of Medicine (D.S.C., K.A.-A., J.C.H., A.M.B., D.D.G.), Cardiovascular Center (A.O.K., D.S.C., K.A.-A., J.C.H., M.J.D., J.K.F., A.M.B., D.D.G.), Department of Physical Medicine and Rehabilitation (M.J.D.), Division of Colorectal Surgery, Department of Surgery (M.F.O.), and Department of Anesthesiology (J.K.F.), Medical College of Wisconsin, Milwaukee.
Mary F OttersonFrom the Department of Physiology (A.O.K., A.M.B., D.D.G.), Division of Cardiology, Department of Medicine (D.S.C., K.A.-A., J.C.H., A.M.B., D.D.G.), Cardiovascular Center (A.O.K., D.S.C., K.A.-A., J.C.H., M.J.D., J.K.F., A.M.B., D.D.G.), Department of Physical Medicine and Rehabilitation (M.J.D.), Division of Colorectal Surgery, Department of Surgery (M.F.O.), and Department of Anesthesiology (J.K.F.), Medical College of Wisconsin, Milwaukee.
Matthew J DurandFrom the Department of Physiology (A.O.K., A.M.B., D.D.G.), Division of Cardiology, Department of Medicine (D.S.C., K.A.-A., J.C.H., A.M.B., D.D.G.), Cardiovascular Center (A.O.K., D.S.C., K.A.-A., J.C.H., M.J.D., J.K.F., A.M.B., D.D.G.), Department of Physical Medicine and Rehabilitation (M.J.D.), Division of Colorectal Surgery, Department of Surgery (M.F.O.), and Department of Anesthesiology (J.K.F.), Medical College of Wisconsin, Milwaukee.
Julie K FreedFrom the Department of Physiology (A.O.K., A.M.B., D.D.G.), Division of Cardiology, Department of Medicine (D.S.C., K.A.-A., J.C.H., A.M.B., D.D.G.), Cardiovascular Center (A.O.K., D.S.C., K.A.-A., J.C.H., M.J.D., J.K.F., A.M.B., D.D.G.), Department of Physical Medicine and Rehabilitation (M.J.D.), Division of Colorectal Surgery, Department of Surgery (M.F.O.), and Department of Anesthesiology (J.K.F.), Medical College of Wisconsin, Milwaukee.
Andreas M BeyerFrom the Department of Physiology (A.O.K., A.M.B., D.D.G.), Division of Cardiology, Department of Medicine (D.S.C., K.A.-A., J.C.H., A.M.B., D.D.G.), Cardiovascular Center (A.O.K., D.S.C., K.A.-A., J.C.H., M.J.D., J.K.F., A.M.B., D.D.G.), Department of Physical Medicine and Rehabilitation (M.J.D.), Division of Colorectal Surgery, Department of Surgery (M.F.O.), and Department of Anesthesiology (J.K.F.), Medical College of Wisconsin, Milwaukee.
David D GuttermanFrom the Department of Physiology (A.O.K., A.M.B., D.D.G.), Division of Cardiology, Department of Medicine (D.S.C., K.A.-A., J.C.H., A.M.B., D.D.G.), Cardiovascular Center (A.O.K., D.S.C., K.A.-A., J.C.H., M.J.D., J.K.F., A.M.B., D.D.G.), Department of Physical Medicine and Rehabilitation (M.J.D.), Division of Colorectal Surgery, Department of Surgery (M.F.O.), and Department of Anesthesiology (J.K.F.), Medical College of Wisconsin, Milwaukee. dgutt@mcw.edu.
MACOM (United States) · US
Funding
Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7MPivotal Role of Mitochondrial Telomerase in Regulation of Vascular Tone and Redox HomeostasisR01HL133029 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BEYER, ANDREAS M · 2017 to 2021
$2.2MNovel Regulatory Mechanisms in the Human MicrocirculationR01HL135901 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GUTTERMAN, DAVID D. · 2017 to 2020
$1.7MMechanism of Flow-Induced Dilation in the Human MicrocirculationR01HL113612 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GUTTERMAN, DAVID D. · 2013 to 2016
$1.7MNHLBI NIH HHS R01 HL113612NHLBI NIH HHS R01 HL133029NHLBI NIH HHS R01 HL135901NIGMS NIH HHS T32 GM080202
Abstract
Blood flow through healthy human vessels releases NO to produce vasodilation, whereas in patients with coronary artery disease (CAD), the mediator of dilation transitions to mitochondria-derived hydrogen peroxide (
Indexed as
Coronary Artery DiseaseHydrogen PeroxidePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaBiological AvailabilityCatalaseCoronary VesselsHumansMicrocirculationModels, BiologicalNitric OxidePolyethylene GlycolsStatistics as TopicVasodilationVasodilator AgentsCatalasecatalase-polyethylene glycolHydrogen PeroxideNitric OxidePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPolyethylene GlycolsVasodilator Agentsarteriolescatalasecoronary artery diseasemicrocirculationnitric oxide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.