ArticleThe Journal of experimental medicine2017
The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh.
Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- E0703 targets ERβ to facilitate the upregulation of GLI3, thereby alleviating irradiation-induced DNA damage on lymphocytes.Cellular & molecular biology letters · 2025Article
- HES1 is required for mouse fetal hematopoiesis.Stem cell research & therapy · 2024Article
- A Metabolic Axis of Immune Intractability.Cancer immunology research · 2024Article
- A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling.Oncotarget · 2022Article
- Review
- The pioneer transcription factors Foxa1 and Foxa2 regulate alternative RNA splicing during thymocyte positive selection.Development (Cambridge, England) · 2021Article
- Fetal liver hematopoiesis: from development to delivery.Stem cell research & therapy · 2021Review
- GLI3: a mediator of genetic diseases, development and cancer.Cell communication and signaling : CCS · 2020Review
- Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation.The Journal of clinical investigation · 2019Article
- IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation.European journal of immunology · 2019Article
- Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus.Frontiers in immunology · 2019Article
- Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells.Cells · 2018Review
- Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets.International journal of molecular sciences · 2018Review
- Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression ofDevelopment (Cambridge, England) · 2018Article
- Taking the Occam's Razor Approach to Hedgehog Lipidation and Its Role in Development.Journal of developmental biology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Before birth, B cells develop in the fetal liver (FL). In this study, we show that Gli3 activity in the FL stroma is required for B cell development. In the Gli3-deficient FL, B cell development was reduced at multiple stages, whereas the Sonic hedgehog (Hh [Shh])-deficient FL showed increased B cell development, and Gli3 functioned to repress
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.