Evidence map›Paper›PMID 28533225›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice.

Kwang Hwa Jung, Wonbeak Yoo, Heather L Stevenson, Dipti Deshpande, Hong Shen, Mihai Gagea, Suk-Young Yoo, Jing Wang, T Kris Eckols, Uddalak Bharadwaj and 2 more

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.

  1. STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review.Journal of experimental & clinical cancer research : CR · 2019
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Metabolic Reprogramming ofCancer communications (London, England) · 2026
    Article
  7. Article
  8. STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer.International journal of molecular sciences · 2025
    Article
  9. Article
  10. STAT3 axis in cancer and cancer stem cells: From oncogenesis to targeted therapies.Biochimica et biophysica acta. Reviews on cancer · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Small-molecule-based targeted therapy in liver cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  18. Review
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Kwang Hwa JungDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Wonbeak YooDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Heather L StevensonDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas.
Dipti DeshpandeDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Hong ShenDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Mihai GageaDepartment of Veterinary Medicine & Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.
Suk-Young YooDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jing WangDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
T Kris EckolsDepartment of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Uddalak BharadwajDepartment of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.
David J TweardyDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Laura BerettaDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. lberetta@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USThe University of Texas Medical Branch at Galveston · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Oral Small Molecule STAT3 Inhibitor to Treat Cachexia in Chronic Kidney DiseaseR42DK104494 · NIDDK · TVARDI THERAPEUTICS, INC. · PI TWEARDY, DAVID JOHN · 2016 to 2017
$1.7M
Targeting Stat1 and Stat3 to Reverse Radioresistance in Head and Neck CancerR21CA191556 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI TWEARDY, DAVID JOHN · 2015 to 2016
$363k
NCI NIH HHS P30 CA016672NCI NIH HHS R21 CA191556NIDDK NIH HHS R42 DK104494
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntineoplastic AgentsBenzenesulfonamidesBiopsyCarcinoma, HepatocellularCell Line, TumorCell ProliferationCell SurvivalCytokinesDisease Models, AnimalGene Expression ProfilingHumansImmunohistochemistryInflammation MediatorsLiver Function TestsLiver NeoplasmsAntineoplastic AgentsBenzenesulfonamidesC188-9 compoundCytokinesInflammation MediatorsNaphtholsPTEN PhosphohydrolaseSTAT3 Transcription FactorSulfonamides

Identifiers

PMID28533225
PMCPMC5873583
OpenAlexW2618875352

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.