Evidence map›Paper›PMID 28533206›Full record

ArticleDevelopment (Cambridge, England)2017

Myostatin-like proteins regulate synaptic function and neuronal morphology.

Hrvoje Augustin, Kieran McGourty, Joern R Steinert, Helena M Cochemé, Jennifer Adcott, Melissa Cabecinha, Alec Vincent, Els F Halff, Josef T Kittler, Emmanuel Boucrot and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Hrvoje AugustinInstitute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.ORCID 0000-0002-2041-3844
Kieran McGourtyInstitute of Structural and Molecular Biology, University College London, Darwin Building Gower Street, London WC1E 6BT, UK.
Joern R SteinertMRC Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.
Helena M CocheméInstitute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.
Jennifer AdcottInstitute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.
Melissa CabecinhaInstitute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.
Alec VincentInstitute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.
Els F HalffDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Josef T KittlerDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Emmanuel BoucrotInstitute of Structural and Molecular Biology, University College London, Darwin Building Gower Street, London WC1E 6BT, UK.
Linda PartridgeInstitute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK partridge@age.mpg.de.ORCID 0000-0001-9615-0094
University College London · GBMax Planck Institute for Biology of Ageing · DEInstitute of Structural and Molecular Biology · GBHammersmith Hospital · GBUniversity of Leicester · GB

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council MC_U132681855Medical Research Council MR/N025644/1Wellcome Trust
6 · The paper itself

Abstract

Growth factors of the TGFβ superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators of skeletal muscle mass. However, expression of myostatin and its cognate receptors in other tissues, including brain and peripheral nerves, suggests a potential wider biological role. Here, we show that Myoglianin (MYO), the

Indexed as

Cell ShapeAnimalsBody WeightDown-RegulationDrosophila melanogasterDrosophila ProteinsGene SilencingGlycogen Synthase Kinase 3Growth Differentiation FactorsHumansLarvaMuscle CellsMyostatinNeurogliaNeuromuscular JunctionNeuronsDrosophila ProteinsGdf11 protein, ratGlycogen Synthase Kinase 3Growth Differentiation FactorsMSTN protein, humanmyo protein, DrosophilaMyostatinSgg protein, DrosophilaTransforming Growth Factor betaDrosophilaGDF11Muscle sizeMyoglianinMyostatinSynapse

Identifiers

PMID28533206
PMCPMC5536874
OpenAlexW2618325602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.