Evidence map›Paper›PMID 28532855›Full record

ArticleBrain research2017

Prenatal high sucrose intake affected learning and memory of aged rat offspring with abnormal oxidative stress and NMDARs/Wnt signaling in the hippocampus.

Axin He, Yingying Zhang, Yuxian Yang, Lingjun Li, Xueqin Feng, Bin Wei, Di Zhu, Yanping Liu, Lei Wu, Lubo Zhang and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Axin HeInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Yingying ZhangInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Yuxian YangInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Lingjun LiInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Xueqin FengInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Bin WeiInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Di ZhuInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Yanping LiuInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Lei WuInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Lubo ZhangInstitute for Fetology, First Hospital of Soochow University, Suzhou, China; Center for Perinatal Biology, Loma Linda University, CA, USA.
Zhice XuInstitute for Fetology, First Hospital of Soochow University, Suzhou, China; Center for Perinatal Biology, Loma Linda University, CA, USA. Electronic address: xuzhice@suda.edu.cn.
Miao SunInstitute for Fetology, First Hospital of Soochow University, Suzhou, China. Electronic address: miaosunsuda@163.com.
First Affiliated Hospital of Soochow University · CNSoochow University · CNLoma Linda University · US

Funding

Developmental Programming of Ischemic-Sensitive Phenotype in the HeartR01HL118861 · NHLBI · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2014 to 2017
$1.8M
NHLBI NIH HHS R01 HL118861
6 · The paper itself

Abstract

Maternal over-nutrition may predispose offspring to obesity, type 2 diabetes and other adult diseases. The present study investigated long-term impact of prenatal high sucrose (HS) diets on cognitive capabilities in aged rat offspring. The fasting plasma glucose concentration did not differ between the control and HS groups. However, the fasting plasma insulin and insulin resistance index values were significantly increased in HS offspring that showed abnormal glucose tolerance test. HS offspring exhibited increased escape latency and swimming path length to the platform, and reduced time in the target quadrant and the number of crossing the platform, as compared with the control group. The expression of Grin2b/NR2B, Wnt2, Wnt3a and active form of β-catenin protein were decreased, and Dickkopf-related protein 1 was increased in the HS group. In addition, the levels of lipid peroxidation biomarker thiobarbituricacid reactive substance, nicotinamide adenine dinucleotide phosphate oxidases 2 and superoxide dismutase 1 were significantly increased, and the activity of catalase was decreased in the hippocampus in the HS group. The results demonstrate that prenatal HS-induced metabolic changes cause cognitive deficits in aged rat offspring, probably due to altered N-methyl-d-aspartate receptors/Wnt signaling and oxidative stress in the hippocampus.

Indexed as

Prenatal Nutritional Physiological PhenomenaAgingAnimalsCatalaseDietary SucroseFemaleHippocampusLearningLipid PeroxidationMaleMemoryOxidative StressPregnancyRandom AllocationRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateCatalaseDietary SucroseReceptors, N-Methyl-D-AspartateRNA, MessengerAged offspringNMDARsOxidative stressPrenatal high sucrose dietsSpatial cognitionWnt/β-catenin

Identifiers

PMID28532855
PMCPMC5639946
OpenAlexW2615389116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.