Evidence map›Paper›PMID 28532642›Full record

ArticleAcademic radiology2017

Optical Mammography in Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy: Individual Clinical Response Index.

Pamela G Anderson, Sirishma Kalli, Angelo Sassaroli, Nishanth Krishnamurthy, Shital S Makim, Roger A Graham, Sergio Fantini

Abstract read
In one paragraph

Article in Academic radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  6. Emerging Breast Imaging Technologies on the Horizon.Seminars in ultrasound, CT, and MR · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pamela G AndersonDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155.
Sirishma KalliDepartment of Radiology, Tufts Medical Center, Boston, Massachusetts.
Angelo SassaroliDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155.
Nishanth KrishnamurthyDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155.
Shital S MakimDepartment of Radiology, Tufts Medical Center, Boston, Massachusetts.
Roger A GrahamDepartment of Surgery, Tufts Medical Center, Boston, Massachusetts.
Sergio FantiniDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155. Electronic address: Sergio.fantini@tufts.edu.
Tufts University · USTufts Medical Center · US

Funding

Near-infrared spectral imaging of the breast for cancer detection and monitoringR01CA154774 · NCI · TUFTS UNIVERSITY MEDFORD · PI FANTINI, SERGIO · 2011 to 2015
$2.2M
NCI NIH HHS R01 CA154774
6 · The paper itself

Abstract

RATIONALE AND

objectivesWe present an optical mammography study that aims to develop quantitative measures of pathologic response to neoadjuvant chemotherapy (NAC) in patients with breast cancer. Such quantitative measures are based on the concentrations of oxyhemoglobin ([HbO MATERIALS AND

methodsContinuous-wave, spectrally resolved optical mammography was performed in transmission and parallel-plate geometry on 10 patients before treatment initiation and at each NAC administration (mean number of optical mammography sessions: 12, range: 7-18). Data on two patients were discarded for technical reasons. The patients were categorized as responders (R, >50% decrease in tumor size), or nonresponders (NR, <50% decrease in tumor size) based on imaging and histopathology results.

resultsAt 50% completion of the NAC regimen (therapy midpoint), R (6/8) demonstrated significant decreases in SO

conclusionsThese results show that optical mammography is a promising tool to assess individual response to NAC at therapy midpoint to guide further decision making for neoadjuvant therapy.

Indexed as

MammographyNeoadjuvant TherapyAdultAgedAntineoplastic AgentsBreast NeoplasmsChemotherapy, AdjuvantFemaleHemoglobinsHumansMiddle AgedOxyhemoglobinsAntineoplastic AgentsdeoxyhemoglobinHemoglobinsOxyhemoglobinsbreast cancernear-infrared spectroscopyneoadjuvant therapyOptical mammography

Identifiers

PMID28532642
PMCPMC5591774
OpenAlexW2615475157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.