ArticleVeterinary research2017
Innate immune responses induced by the saponin adjuvant Matrix-M in specific pathogen free pigs.
Article in Veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Saponin TQL1055 adjuvant-containing vaccine confers protection uponHuman vaccines & immunotherapeutics · 2024Article
- The Matrix-M™ adjuvant: A critical component of vaccines for the 21Human vaccines & immunotherapeutics · 2023Review
- Emerging adjuvants for intradermal vaccination.International journal of pharmaceutics · 2023Review
- Immunogenicity of a recombinant hemagglutinin neuraminidase-Porcine rubulavirus produced by Escherichia coli of Porcine rubulavirus gives protective immunity of litter after challenge.The Journal of veterinary medical science · 2022Article
- Congenital tremor and splay leg in piglets - insights into the virome, local cytokine response, and histology.BMC veterinary research · 2022Article
- Development of a 3-transcript host expression assay to differentiate between viral and bacterial infections in pigs.PloS one · 2021Article
- The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development.Frontiers in immunology · 2020Review
- Re-evaluation of Quillaia extract (E 999) as a food additive and safety of the proposed extension of use.EFSA journal. European Food Safety Authority · 2019Article
- Saponins fromMolecules (Basel, Switzerland) · 2019Review
- Characterisation of the Virome of Tonsils from Conventional Pigs and from Specific Pathogen-Free Pigs.Viruses · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saponin-based adjuvants have been widely used to enhance humoral and cellular immune responses in many species, but their mode of action is not fully understood. A characterization of the porcine transcriptional response to Matrix-M was performed in vitro using lymphocytes, monocytes or monocyte-derived dendritic cells (MoDCs) and in vivo. The effect of Matrix-M was also evaluated in specific pathogen free (SPF) pigs exposed to conventionally reared pigs. The pro-inflammatory cytokine genes IL1B and CXCL8 were up-regulated in monocytes and lymphocytes after Matrix-M exposure. Matrix-M also induced IL12B, IL17A and IFNG in lymphocytes and IFN-α gene expression in MoDCs. Several genes were indicated as up-regulated by Matrix-M in blood 18 h after injection, of which the genes for IFN-α and TLR2 could be statistically confirmed. Respiratory disease developed in all SPF pigs mixed with conventional pigs within 1-3 days. Two out of four SPF pigs injected with saline prior to contact exposure displayed systemic symptoms that was not recorded for the four pigs administered Matrix-M. Granulocyte counts, serum amyloid A levels and transcription of IL18 and TLR2 coincided with disease progression in the pigs. These results support further evaluation of Matrix-M as a possible enhancer of innate immune responses during critical moments in pig management.
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