Evidence map›Paper›PMID 28532435›Full record

ArticleBMC molecular biology2017

Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system.

Rebecca R Minich, Jin Li, Bruce L Tempel

Open access · hybridAbstract read
In one paragraph

Article in BMC molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Gene-specific DNA methylation responses to PbEnvironmental epigenetics · 2026
    Article
  2. Article
  3. Article
  4. Intensive stretch-activated CRT-PMCA1 feedback loop promoted apoptosis of myoblasts through CaApoptosis : an international journal on programmed cell death · 2022
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rebecca R MinichDepartment of Pharmacology, School of Medicine, University of Washington, Seattle, WA, 98195, USA. minire@uw.edu.ORCID 0000-0002-8700-237X
Jin LiDepartment of Pharmacology, School of Medicine, University of Washington, Seattle, WA, 98195, USA.
Bruce L TempelDepartment of Pharmacology, School of Medicine, University of Washington, Seattle, WA, 98195, USA. bltempel@uw.edu.
University of Washington · US

Funding

UNIVERSITY OF WASHINGTON RESEARCH CORE CENTERP30DC004661 · NIDCD · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W, STONE, JENNIFER S. · 2000 to 2014
$11.1M
Auditory Neuroscience Traning ProgramT32DC005361 · NIDCD · UNIVERSITY OF WASHINGTON · PI Adrian KC Lee, DAVID J PERKEL · 2002 to 2026
$8.8M
GENETIC MODEL FOR CONGENITAL DEAFNESSR01DC002739 · NIDCD · UNIVERSITY OF WASHINGTON · PI TEMPEL, BRUCE L · 1995 to 2013
$4.1M
LincRNAs Regulate Atp2b2, Potentially Determining PMCA2 Quantity in StereociliaR21DC014864 · NIDCD · UNIVERSITY OF WASHINGTON · PI TEMPEL, BRUCE L · 2015 to 2016
$407k
NIDCD NIH HHS P30 DC004661NIDCD NIH HHS R01 DC002739NIDCD NIH HHS R21 DC014864NIDCD NIH HHS T32 DC005361
6 · The paper itself

Abstract

backgroundAlong with sodium/calcium (Ca

resultsAlthough ATP2Bs are important regulators of Ca

conclusionThis study furthers our understanding of Atp2b2 regulation by: (I) elucidating transcriptional regulatory mechanisms for Atp2b2, and (II) identifying transcription factors that modulate expression of Atp2b2 in the brain and peripheral auditory system and (III) allows for future studies modulating gene expression of Atp2b2.

Indexed as

Gene Expression RegulationPromoter Regions, GeneticAnimalsAuditory CortexBrainCalciumCell LineCerebellumCpG IslandsEarly Growth Response Protein 1HaploinsufficiencyMicePlasma Membrane Calcium-Transporting ATPasesProtein BindingTranscription FactorsTranscription, GeneticAtp2b2 protein, mouseCalciumEarly Growth Response Protein 1Plasma Membrane Calcium-Transporting ATPasesTranscription FactorsAtonal bHLH transcription factor 1 (ATOH1)Early growth response protein 1 (EGR1)Gene regulationGene transcriptionMinimal promoterPlasma membrane calcium ATPase 2 (ATP2B2)Plasma membrane calcium-transporting ATPase 4 (ATP2B4)Promoter

Identifiers

PMID28532435
PMCPMC5441030
OpenAlexW2619322732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.