Evidence map›Paper›PMID 28532365›Full record

ArticleAnnual review of vision science2015

Functional Circuitry of the Retina.

Jonathan B Demb, Joshua H Singer

Abstract read
In one paragraph

Article in Annual review of vision science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed.

  1. Harmonics added to a flickering light can upset the balance between ON and OFF pathways to produce illusory colors.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Trial
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  7. Antioxidants (Basel, Switzerland) · 2026
    Article
  8. Article
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  13. The non-opponent nature of colour afterimages.Communications psychology · 2025
    Article
  14. Review
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  16. Article
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  18. Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jonathan B DembDepartment of Ophthalmology and Visual Science and Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06511; email: jonathan.demb@yale.edu.
Joshua H SingerDepartment of Biology, University of Maryland, College Park, Maryland 20742; email: jhsinger@umd.edu.

Funding

Synaptic Transmission in The Rod Pathway of the Mammalian RetinaR01EY017836 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI Jonathan B Demb, Anastas Popratiloff · 2007 to 2026
$7.2M
Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI In-Jung Kim · 2016 to 2026
$7.1M
Neural Circuits and Synapses for Early Visual ProcessingR01EY014454 · NEI · YALE UNIVERSITY · PI DEMB, JONATHAN B · 2005 to 2022
$6.7M
CRCNS: Biophysical properties of parallel neural circuits serving night visionR01EY021372 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI DEMB, JONATHAN B, SINGER, JOSHUA H · 2010 to 2016
$2.1M
NEI NIH HHS P30 EY026878NEI NIH HHS R01 EY014454NEI NIH HHS R01 EY017836NEI NIH HHS R01 EY021372
6 · The paper itself

Abstract

The mammalian retina is an important model system for studying neural circuitry: Its role in sensation is clear, its cell types are relatively well defined, and its responses to natural stimuli-light patterns-can be studied in vitro. To solve the retina, we need to understand how the circuits presynaptic to its output neurons, ganglion cells, divide the visual scene into parallel representations to be assembled and interpreted by the brain. This requires identifying the component interneurons and understanding how their intrinsic properties and synapses generate circuit behaviors. Because the cellular composition and fundamental properties of the retina are shared across species, basic mechanisms studied in the genetically modifiable mouse retina apply to primate vision. We propose that the apparent complexity of retinal computation derives from a straightforward mechanism-a dynamic balance of synaptic excitation and inhibition regulated by use-dependent synaptic depression-applied differentially to the parallel pathways that feed ganglion cells.

Indexed as

adaptationamacrine cellbipolar cellganglion cellparallel pathwayssynaptic depression

Identifiers

PMID28532365
PMCPMC5749398

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.