Evidence map›Paper›PMID 28531964›Full record

ArticleRedox biology2017

Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription.

Antonina N Shvetsova, Daniela Mennerich, Juha M Kerätär, J Kalervo Hiltunen, Thomas Kietzmann

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Identification of DownregulatedInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Molecular Mechanisms of High-Altitude Acclimatization.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Hypoxia and HIF Signaling: One Axis with Divergent Effects.International journal of molecular sciences · 2020
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Antonina N ShvetsovaFaculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.
Daniela MennerichFaculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.
Juha M KerätärFaculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.
J Kalervo HiltunenFaculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.
Thomas KietzmannFaculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland. Electronic address: Thomas.Kietzmann@oulu.fi.
University of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria are the main consumers of molecular O

Indexed as

Transcription, GeneticAnimalsCell HypoxiaCitric Acid CycleGene Expression RegulationHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsMiceMitochondriaMouse Embryonic Stem CellsNIH 3T3 CellsOxidoreductases Acting on CH-CH Group DonorsProteolysisReactive Oxygen SpeciesSuperoxide DismutaseHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsMpv17 protein, mouseOxidoreductases Acting on CH-CH Group DonorsReactive Oxygen SpeciesSuperoxide Dismutasetrans-2-enoyl-CoA reductase (NADPH)HIF-1αHypoxiaMFAS IIMitochondrial defectsMnSODMpv17

Identifiers

PMID28531964
PMCPMC5440747
OpenAlexW2612965129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.