Evidence map›Paper›PMID 28531379›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017

The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study.

Kathleen M Hayden, Daniel P Beavers, Susan E Steck, James R Hebert, Fred K Tabung, Nitin Shivappa, Ramon Casanova, JoAnn E Manson, Claudia B Padula, Elena Salmoirago-Blotcher and 3 more

Open access · greenAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 5 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 5 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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  20. Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Kathleen M HaydenDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: khayden@wakehealth.edu.
Daniel P BeaversDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Susan E SteckCancer Prevention and Control Program, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
James R HebertCancer Prevention and Control Program, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA; Connecting health Innovations, LLC, Columbia, SC, USA.
Fred K TabungDepartments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nitin ShivappaCancer Prevention and Control Program, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA; Connecting health Innovations, LLC, Columbia, SC, USA.
Ramon CasanovaDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Claudia B PadulaVA Palo Alto Health Care System and Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Elena Salmoirago-BlotcherCenters for Behavioral and Preventive Medicine, The Miriam Hospital; Departments of Medicine and Epidemiology, Warren Alpert School of Medicine and School of Public Health, Brown University, Providence, RI, USA.
Linda G SnetselaarDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA.
Oleg ZaslavskyDepartment of Behavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle, WA, USA.
Stephen R RappDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Psychiatry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Wake Forest University · USConnecting Health Innovations (United States) · USBrigham and Women's Hospital · USBrown University · USHarvard University · USUniversity of Iowa · USUniversity of South Carolina · USUniversity of Washington · USVA Palo Alto Health Care System · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Tomas Vaisar · 1986 to 2026
$41.4M
Clonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9M
Developing the Dietary Inflammatory Index for Clinical ApplicationR44DK103377 · NIDDK · CONNECTING HEALTH INNOVATIONS, LLC · PI SHIVAPPA, NITIN, WIRTH, MICHAEL DAVID · 2014 to 2016
$1.8M
Proinflammatory and hyperinsulinemic dietary patterns and colorectal cancer risk: role of the metabolomeK99CA207736 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI TABUNG, FRED KINYUY · 2016 to 2017
$276k
NCI NIH HHS K99 CA207736NHLBI NIH HHS R01 HL148565NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R44 DK103377
6 · The paper itself

Abstract

introductionThe Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk.

methodsBaseline food frequency questionnaires from n = 7085 women (aged 65-79 years) were used to calculate Dietary Inflammatory Index (DII) scores that were categorized into four groups. Cognitive function was evaluated annually, and MCI and all-cause dementia cases were adjudicated centrally. Mixed effect models evaluated cognitive decline on over time; Cox models evaluated the risk of MCI or dementia across DII groups.

resultsOver an average of 9.7 years, there were 1081 incident cases of cognitive impairment. Higher DII scores were associated with greater cognitive decline and earlier onset of cognitive impairment. Adjusted hazard ratios (HRs) comparing lower (anti-inflammatory; group 1 referent) DII scores to the higher scores were group 2-HR: 1.01 (0.86-1.20); group 3-HR: 0.99 (0.82-1.18); and group 4-HR: 1.27 (1.06-1.52).

conclusionsDiets with the highest pro-inflammatory potential were associated with higher risk of MCI or dementia.

Indexed as

Women's HealthAgedCognitive DysfunctionDementiaDietDiet SurveysFemaleHumansIncidenceInflammationProportional Hazards ModelsSurveys and QuestionnairesCognitive declineDementiaDietInflammationMild cognitive impairmentSurvival analysis

Identifiers

PMID28531379
PMCPMC5909961
OpenAlexW2616762494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.