ArticleNeuro-oncology2017
Prognostic significance of preoperative neutrophilia on recurrence-free survival in meningioma.
Article in Neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Prognostic value of pretreatment serum albumin-globulin ratio in urothelial carcinoma: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Profiling of rare immune cell populations and integrative analysis identify immune ecotypes in newly diagnosed meningiomas.Acta neuropathologica communications · 2026Article
- Pre-operative blood-based inflammatory indices and long-term facial nerve outcomes following vestibular schwannoma resection.Journal of neuro-oncology · 2026Article
- The dural attachment length predict prognosis in patients with recurrent meningiomas.Neurosurgical review · 2024Article
- Based on clinical Ki-67 expression and serum infiltrating lymphocytes related nomogram for predicting the diagnosis of glioma-grading.Frontiers in oncology · 2022Article
- Identification of diagnostic and prognostic signatures derived from preoperative blood parameters for oral squamous cell carcinoma.Annals of translational medicine · 2021Article
- DNA repair and cell synthesis proteins: immunohistochemical expression and correlation with recurrence-regrowth in meningiomas.Journal of molecular histology · 2020Article
- Article
- WHO grade I meningiomas: classification-tree for prognostic factors of survival.Neurosurgical review · 2020Article
- Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas.Frontiers in oncology · 2020Article
- A comprehensive study of risk factors for post-operative pneumonia following resection of meningioma.BMC cancer · 2019Article
- Meningioma transcription factors link cell lineage with systemic metabolic cues.Neuro-oncology · 2018Article
- Elevated neutrophil-to-lymphocyte ratio as a prognostic factor in primary central nervous system lymphoma.Neuro-oncology advancesArticle
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeningioma is the most common primary intracranial tumor and recurrence is one of the important challenges in patient management. Prognostic factors for tumor recurrences in these patients especially before surgical resection are not fully characterized. Several studies have indicated an association between changes in hematologic laboratory parameters with patient outcomes in solid malignancies. We aimed to assess the association between hematologic parameters and tumor recurrence in patients with meningioma.
methodsPreoperative complete blood count (CBC) data were analyzed in patients with newly diagnosed meningioma (n = 222). Clinical data, including history of corticosteroid therapy, tumor characteristics, and follow-up, were obtained. Recurrence-free survival (RFS) was evaluated using Cox proportional hazards models and log-rank tests.
resultsUsing preoperative CBC data from patients prior to any steroid therapy, 51 (23%) patients had neutrophilia. In univariate analysis, neutrophilia was significantly associated with meningioma recurrence (hazard ratio [HR] 2.73; P < 0.01). Neither leukocytosis nor lymphocytosis was associated with RFS. In multivariate analysis, after adjusting for tumor grade, tumor size, and extent of resection, neutrophilia remained an independent prognostic factor for RFS (HR 2.23, P = 0.01). Forty-six (21%) patients had low hemoglobin levels indicative of anemia, and the presence of anemia showed a trend toward high risk for recurrence (HR 1.83; P = 0.06).
conclusionsThe presence of neutrophilia was associated with higher rate of tumor recurrence in patients with meningioma. Validation of these results and the biologic role of neutrophilic inflammatory/immune reaction in meningioma requires further investigation.
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