Evidence map›Paper›PMID 28531300›Full record

ReviewChemical senses2017

Anosmia-A Clinical Review.

Sanne Boesveldt, Elbrich M Postma, Duncan Boak, Antje Welge-Luessen, Veronika Schöpf, Joel D Mainland, Jeffrey Martens, John Ngai, Valerie B Duffy

Erratum issued 2 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Chemical senses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 161 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 7 pooled it
18.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04495816 phase2completednot on this mapstarted 2020, after this paper: background citation

COVID-19 Anosmia Study

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2020 to 2021Enrolled139ConditionsAnosmia, Covid19ArmsOmega-3 Fatty Acid Supplement, Placebo/Control
NCT04710394 nacompletednot on this mapstarted 2021, after this paper: background citation

Efficacy of Bimodal Visual-Olfactory Training in Participants With COVID-19 Resultant Hyposmia or Anosmia Using Participant-Preferred Scents

TypeinterventionalSponsorWashington University School of MedicineRan2021 to 2022Enrolled240ConditionsAnosmia, Covid19, Ageusia, HyposmiaArmsSmell Training
3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 7 syntheses or guidelines pooled it, 354 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Efficacy of topical steroids for the treatment of olfactory disorders caused by COVID-19: A systematic review and meta-analysis.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2022
    Pooled it
  4. Pooled it
  5. Olfactory function in patients with obstructive sleep apnea: a meta-analysis study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Pooled it
  6. Pooled it
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  8. Trial
  9. Trial
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  11. Article
  12. Article
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  17. Smell and taste dysfunction after total laryngectomy: A cross-sectional study comparing patient and physician perspectives.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  18. Article
  19. Smell Is Emotion.Brain sciences · 2025
    Article
  20. Validation of the Hebrew version of the "Sniffin' Sticks" olfactory test: a cross-sectional study in an Israeli cohort.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 5 countries.

Sanne BoesveldtDivision of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.
Elbrich M PostmaDivision of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.
Duncan BoakFifth Sense, Sanderum House, 38 Oakley Road, Chino OX39 4TW, UK.
Antje Welge-LuessenDepartment of Otorhinolaryngology, University Hospital Basel, Petersgraben 4CH-4031 Basel, Switzerland.
Veronika SchöpfInstitute of Psychology, University of Graz, Universitätsplatz 2, 8010 Graz, Austria.
Joel D MainlandMonell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA.
Jeffrey MartensDepartment of Pharmacology & Therapeutics, University of Florida, Gainesville, FL, USA.
John NgaiDepartment of Molecular & Cell Biology, University of California, Berkeley, CA 94720-3200, USA.
Valerie B DuffyDepartment of Allied Health Sciences, University of Connecticut, 358 Mansfield Road, Box U-101 Storrs, CT 06269-2101, USA.
Barnsley Hospital · GBMonell Chemical Senses Center · USUniversity Hospital of Basel · CHUniversity of California, Berkeley · USUniversity of Connecticut · USUniversity of Florida · USUniversity of Graz · ATWageningen University & Research · NLZiekenhuis Gelderse Vallei · NL

Funding

Supplement for Programs of Gene Expression in Olfactory NeurogenesisR01DC007235 · NIDCD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUDOIT, SANDRINE · 2005 to 2022
$6.6M
Perceptual effects of genetic variation in human odorant receptorsR01DC013339 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI MAINLAND, JOEL D · 2013 to 2017
$1.9M
NIDCD NIH HHS R01 DC007235NIDCD NIH HHS R01 DC013339
6 · The paper itself

Abstract

Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3-20% of the population. Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases. These disorders impair the ability to sense warning odors in foods and the environment, as well as hinder the quality of life related to social interactions, eating, and feelings of well-being. This article reports and extends on a clinical update commencing at the 2016 Association for Chemoreception Sciences annual meeting. Included were reports from: a patient perspective on losing the sense of smell with information on Fifth Sense, a nonprofit advocacy organization for patients with olfactory disorders; an otolaryngologist's review of clinical evaluation, diagnosis, and management/treatment of anosmia; and researchers' review of recent advances in potential anosmia treatments from fundamental science, in animal, cellular, or genetic models. As limited evidence-based treatments exist for anosmia, dissemination of information on anosmia-related health risks is needed. This could include feasible and useful screening measures for olfactory dysfunction, appropriate clinical evaluation, and patient counseling to avoid harm as well as manage health and quality of life with anosmia.

Indexed as

Delivery of Health CareHumansNeuronal PlasticityOlfaction DisordersPrognosisQuality of LifeSmellStem Cell Transplantationgeneticsneural reorganizationolfactory dysfunctionquality of lifestem cell regenerationtreatment

Identifiers

PMID28531300
PMCPMC5863566
OpenAlexW2617614562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.