ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Impact of Vitamin A and Carotenoids on the Risk of Tuberculosis Progression.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Association of variant vitamin statuses and tuberculosis development: a systematic review and meta-analysis.Annals of medicine · 2024Pooled it
- Influence of Vitamin A supplementation on inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials.Scientific reports · 2022Pooled it
- Could Vitamins Help in the Fight Against COVID-19?Nutrients · 2020Pooled it
- Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis.PLoS medicine · 2019Pooled it
- The Impact of Vitamin A Deficiency on Tuberculosis Progression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study.BMC medicine · 2018Trial
- Infection with Mycobacterium tuberculosis depletes host fatty acids in humans and non-human primates.EBioMedicine · 2026Article
- Body Mass Index and Incident Tuberculosis in Close Tuberculosis Contacts.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Observational
- A Plasma Metabolic Signature to Diagnose Pulmonary Tuberculosis and Monitor Treatment Response.The Journal of infectious diseases · 2025Article
- Vitamin A and Its Related Diseases.Food science & nutrition · 2025Review
- Modelling the effect of a nutritional shock on tuberculosis in India.BMC global and public health · 2025Article
- Micronutrient status and risk of Mycobacterium tuberculosis infection in Indonesian tuberculosis case contacts.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025Article
- Global burden and cross-country inequalities of nutritional deficiencies in adults aged 65 years and older, 1990-2021: population-based study using the GBD 2021.BMC geriatrics · 2025Article
- The global burden of tuberculosis attributable to diet high in processed meat from 1990 to 2021: findings from the Global Burden of Disease Study 2021.Frontiers in nutrition · 2025Article
- Food insecurity in South Indian households with TB during COVID-19 lockdowns and the impact of nutritional interventions: A qualitative study.PLOS global public health · 2025Article
- Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease.Frontiers in endocrinology · 2025Review
- Bioguided Optimization of the Nutrition-Health, Antioxidant, and Immunomodulatory Properties ofNutrients · 2024Article
- Unmasking the hidden impact of viruses on tuberculosis risk.Trends in immunology · 2024Review
- The Role of Oxidative Stress in Hypertension: The Insight into Antihypertensive Properties of Vitamins A, C and E.Antioxidants (Basel, Switzerland) · 2024Review
- Dietary patterns and micronutrients in respiratory infections including COVID-19: a narrative review.BMC public health · 2024Review
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundLow and deficient levels of vitamin A are common in low- and middle-income countries where tuberculosis burden is high. We assessed the impact of baseline levels of vitamin A and carotenoids on tuberculosis disease risk.
methodsWe conducted a case-control study nested within a longitudinal cohort of household contacts (HHCs) of pulmonary tuberculosis case patients in Lima, Peru. We defined case patients as human immunodeficiency virus (HIV)-negative HHCs with blood samples in whom tuberculosis disease developed ≥15 days after enrollment of the index patient. For each case patient, we randomly selected 4 controls from among contacts in whom tuberculosis disease did not develop, matching for sex and year of age. We used conditional logistic regression to estimate odds ratios for incident tuberculosis disease by vitamin A and carotenoids levels, controlling for other nutritional and socioeconomic factors.
resultsAmong 6751 HIV-negative HHCs with baseline blood samples, 192 had secondary tuberculosis disease during follow-up. We analyzed 180 case patients with viable samples and 709 matched controls. After controlling for possible confounders, we found that baseline vitamin A deficiency was associated with a 10-fold increase in risk of tuberculosis disease among HHCs (adjusted odds ratio, 10.53; 95% confidence interval, 3.73-29.70; P < .001). This association was dose dependent, with stepwise increases in tuberculosis disease risk with each decreasing quartile of vitamin A level.
conclusionsVitamin A deficiency strongly predicted the risk of incident tuberculosis disease among HHCs of patients with tuberculosis. Vitamin A supplementation among individuals at high risk of tuberculosis may provide an effective means of preventing tuberculosis disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.