ReviewJournal of dental research2017
Developing a New Generation of Antimicrobial and Bioactive Dental Resins.
Review in Journal of dental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed.
- Effectiveness of experimental composites containing antimicrobial agents for orthodontic applications.Odontology · 2026Article
- Review
- Advanced Dental Composite Technology via Bisilanized Dual-Action Nanofillers for Biofilm Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Antibacterial activity of a bioactive composite resins containing surface pre-reacted glass in a complex multispecies subgingival biofilm.Odontology · 2026Article
- Review
- Cytotoxicity and Genotoxicity of Resin-Based Dental Composites Modified with Quaternary Ammonium Salts.Journal of functional biomaterials · 2025Article
- Long-term water immersion of dental composites based on bioactive glass.Scientific reports · 2025Article
- Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Modification of Ti13Nb13Zr Alloy Surface via Plasma Electrolytic Oxidation and Silver Nanoparticles Decorating.Materials (Basel, Switzerland) · 2025Article
- Designing Antibacterial-Based Quaternary Ammonium Coatings (Surfaces) or Films for Biomedical Applications: Recent Advances.International journal of molecular sciences · 2024Review
- Unraveling Nanomaterials in Biomimetic Mineralization of Dental Hard Tissue: Focusing on Advantages, Mechanisms, and Prospects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Antibacterial Dental Adhesive Containing Cetylpyridinium Chloride Montmorillonite.Materials (Basel, Switzerland) · 2024Article
- In vitro analysis of a novel dimethylaminododecyl methacrylate modification of dental acrylic soft liner material.Scientific reports · 2024Article
- Enhancing the Antimicrobial Properties of Experimental Resin-Based Dental Composites through the Addition of Quaternary Ammonium Salts.Journal of functional biomaterials · 2024Article
- Long-term application of silver nanoparticles in dental restoration materials: potential toxic injury to the CNS.Journal of materials science. Materials in medicine · 2023Review
- Restorative Dental Resin Functionalized with Calcium Methacrylate with a Hydroxyapatite Remineralization Capacity.Materials (Basel, Switzerland) · 2023Article
- Anticariogenic Activity of Celastrol and Its Enhancement of Streptococcal Antagonism in Multispecies Biofilm.Antibiotics (Basel, Switzerland) · 2023Article
- Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer.Journal of functional biomaterials · 2023Article
- Antibacterial Activity of a Bioactive Tooth-Coating Material Containing Surface Pre-Reacted Glass in a Complex Multispecies Subgingival Biofilm.Pharmaceutics · 2023Article
- Antibacterial coatings on orthopedic implants.Materials today. Bio · 2023Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Dental caries is prevalent, and secondary caries causes restoration failures. This article reviews recent studies on developing a new generation of bioactive resins with anticaries properties. Extensive effects were made to develop new antimicrobial composites, bonding agents, and other resins containing quaternary ammonium methacrylates to suppress plaque buildup and bacterial acid production. The effects of alkyl chain length and charge density and the antimicrobial mechanisms for chlorhexidine, nano-silver, quaternary ammonium methacrylates, and protein-repellent agents were discussed. Synergistic effects of contact-killing and protein-repellent properties were shown to yield the greatest biofilm-inhibition effects. The combination of antimicrobial, protein-repellent, and calcium phosphate nanoparticle remineralization was suggested to provide maximal anticaries effects. In addition, for use orally, cytotoxicity and biocompatibility were important considerations for the new bioactive materials. Furthermore, rather than kill all bacteria, it would be more desirable to modulate the oral biofilm compositions via bioactive resins to suppress cariogenic/pathogenic species and promote benign species. For widespread clinical use of the new antimicrobial and therapeutic materials, whether they would induce bacterial drug resistance needs to be determined, which requires further study. Nonetheless, the new generation of bioactive anticaries resins with therapeutic and biofilm acid-inhibiting properties has the potential to substantially benefit oral health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.