Evidence map›Paper›PMID 28530834›Full record

ArticleJournal of medicinal chemistry2017

A Facile Radiolabeling of [

Lu Wang, Ran Cheng, Masayuki Fujinaga, Jian Yang, Yiding Zhang, Akiko Hatori, Katsushi Kumata, Jing Yang, Neil Vasdev, Yunfei Du and 3 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Preclinical characterization of [Acta pharmacologica Sinica · 2025
    Article
  2. Review
  3. Review
  4. TSPO Radioligands for Neuroinflammation: An Overview.Molecules (Basel, Switzerland) · 2024
    Review
  5. SyntheticRSC medicinal chemistry · 2024
    Review
  6. Article
  7. Review
  8. State of the art procedures towards reactive [EJNMMI radiopharmacy and chemistry · 2023
    Review
  9. Article
  10. A novel monoacylglycerol lipase-targetedActa pharmacologica Sinica · 2022
    Article
  11. Review
  12. Article
  13. Direct Comparison of [Molecular imaging and biology · 2022
    Article
  14. Preclinical and clinical study on [European journal of nuclear medicine and molecular imaging · 2022
    Article
  15. Easily automated radiosynthesis of [Frontiers in bioengineering and biotechnology · 2022
    Article
  16. Review
  17. TSPO imaging in animal models of brain diseases.European journal of nuclear medicine and molecular imaging · 2021
    Review
  18. Review
  19. Comparative [Adipocyte · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lu WangDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Harvard Medical School , Boston, Massachusetts 02114, United States.
Ran ChengDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Harvard Medical School , Boston, Massachusetts 02114, United States.
Masayuki FujinagaDepartment of Radiopharmaceutics Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , Chiba 263-8555, Japan.
Jian YangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Harvard Medical School , Boston, Massachusetts 02129, United States.
Yiding ZhangDepartment of Radiopharmaceutics Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , Chiba 263-8555, Japan.
Akiko HatoriDepartment of Radiopharmaceutics Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , Chiba 263-8555, Japan.
Katsushi KumataDepartment of Radiopharmaceutics Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , Chiba 263-8555, Japan.
Jing YangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Harvard Medical School , Boston, Massachusetts 02129, United States.
Neil VasdevDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Harvard Medical School , Boston, Massachusetts 02114, United States.
Yunfei DuSchool of Pharmaceutical Science and Technology, Tianjin University , 92 Weijin Road, Nankai District, Tianjin, China.ORCID 0000-0002-0213-2854
Chongzhao RanAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Harvard Medical School , Boston, Massachusetts 02129, United States.
Ming-Rong ZhangDepartment of Radiopharmaceutics Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , Chiba 263-8555, Japan.ORCID 0000-0002-3001-9605
Steven H LiangDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Harvard Medical School , Boston, Massachusetts 02114, United States.ORCID 0000-0003-1413-6315

Funding

New PET tracers for neuroimaging of FAAH in endocannabinoid signalingK01DA038000 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2014 to 2018
$927k
NIDA NIH HHS K01 DA038000
6 · The paper itself

Abstract

A suitable TSPO PET ligand may visualize and quantify neuroinflammation in a living brain. Herein we report a

Indexed as

AnimalsAutoradiographyBrainCarrier ProteinsChemistry Techniques, SyntheticContrast MediaDisease Models, AnimalEncephalitisFluorine RadioisotopesIsotope LabelingMice, TransgenicOnium CompoundsPositron-Emission TomographyPyrazolesPyrimidinesRats, Sprague-DawleyCarrier ProteinsContrast MediaFluorine RadioisotopesN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamideOnium CompoundsPyrazolesPyrimidinesReceptors, GABA-ATspo protein, rat

Identifiers

PMID28530834
PMCPMC5576052

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.