Evidence map›Paper›PMID 28530674›Full record

SynthesisNature genetics2017

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

Joanna M M Howson, Wei Zhao, Daniel R Barnes, Weang-Kee Ho, Robin Young, Dirk S Paul, Lindsay L Waite, Daniel F Freitag, Eric B Fauman, Elias L Salfati and 64 more

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03315234 (Correlation of Genetic Polymorphisms and Clinical Parameters With the Complexity of Coronary Artery Disease in the Greek Population), which is not on this map. Cited by 200 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03315234 unknown statusnot on this map

Correlation of Genetic Polymorphisms and Clinical Parameters With the Complexity of Coronary Artery Disease in the Greek Population

Typeobservational_patient_registrySponsorAristotle University Of ThessalonikiRan2016 to 2021Enrolled270ConditionsCoronary Artery Disease, Cardiovascular Risk Factor, Coronary ArteriosclerosisArmsSNPs associated with CAD
3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  20. Signaling pathways regulating cardiac regeneration.Cell regeneration (London, England) · 2026
    Review

140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

74 authors.

Joanna M M HowsonMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Wei ZhaoDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0002-8301-9297
Daniel R BarnesMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Weang-Kee HoMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Robin YoungMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Dirk S PaulMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8230-0116
Lindsay L WaiteHudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA.
Daniel F FreitagMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Eric B FaumanPfizer Worldwide Research and Development, Cambridge, Massachusetts, USA.
Elias L SalfatiDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Benjamin B SunMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
John D EicherNational Heart, Lung, and Blood Institute, Population Sciences Branch, Bethesda, Maryland, USA.
Andrew D JohnsonNational Heart, Lung, and Blood Institute, Population Sciences Branch, Bethesda, Maryland, USA.
Wayne H H SheuDivision of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Sune F NielsenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Wei-Yu LinMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9267-7988
Praveen SurendranMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Anders MalarstigPfizer Worldwide Research and Development, Stockholm, Sweden.
Jemma B WilkPfizer Worldwide Research and Development, Human Genetics, Cambridge, Massachusetts, USA.
Anne Tybjærg-HansenDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Katrine L RasmussenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Pia R KamstrupDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-9251-070X
Jeanette ErdmannInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Sekar KathiresanCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Heribert SchunkertDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Hugh WatkinsRadcliffe Department of Medicine, University of Oxford, Oxford, UK.
CARDIoGRAMplusC4D
Ron DoCharles Bronfman Institute for Personalized Medicine, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Daniel J RaderDepartments of Genetics, Medicine, and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Julie A JohnsonUniversity of Florida College of Pharmacy, Gainesville, Florida, USA.
Stanley L HazenDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, Ohio, USA.
Arshed A QuyyumiDivision of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.
John A SpertusSaint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.
Carl J PepineCollege of Medicine, University of Florida, Gainesville, Florida, USA.
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Anne JusticeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Alex P ReinerDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Steven BuyskeDepartment of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey, USA.ORCID http://orcid.org/0000-0001-8539-5416
Lucia A HindorffDivision of Genomic Medicine, National Human Genome Research Institute, US National Institutes of Health, Bethesda,Maryland, USA.ORCID http://orcid.org/0000-0002-4414-3236
Cara L CartyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Kristin YoungDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0003-0070-6145
Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA.
Chao A HsiungDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Ying-Hsiang ChenDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
I-Te LeeSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Ren-Hua ChungDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Yi-Jen HungCollege of Medicine, National Defense Medical Center, Taipei, Taiwan.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Jyh-Ming J JuangCardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Thomas QuertermousDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Tzung-Dau WangCardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Asif RasheedCentre for Non-Communicable Disease, Karachi, Pakistan.
Philippe FrossardCentre for Non-Communicable Disease, Karachi, Pakistan.
Dewan S AlamSchool of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
Abdulla Al Shafi MajumderNational Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Bangladesh.
Emanuele Di AngelantonioMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Rajiv ChowdhuryMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
EPIC-CVD
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Børge G NordestgaardDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Themistocles L AssimesDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
John DaneshMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Adam S ButterworthMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Danish SaleheenMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
T32 Training Program in Mechanisms and Innovation in Vascular DiseaseT32HL098049 · NHLBI · STANFORD UNIVERSITY · PI Nicholas James Leeper, Philip S Tsao · 2010 to 2026
$6.3M
Leveraging Hispanic/Latino diversity to map and characterize cardiovascular disease lociR01HL163262 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Lindsay Fernandez-Rhodes, Mariaelisa Graff · 2023 to 2026
$2.9M
Determinants of Insulin Mediated Glucose uptake in South AsiansK23DK088942 · NIDDK · STANFORD UNIVERSITY · PI ASSIMES, THEMISTOCLES LEONARD · 2011 to 2014
$724k
FHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600k
APOL1, sickle cell trait and chronic kidney disease in African AmericansR56DK104806 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA, REINER, ALEXANDER P · 2016 to 2016
$300k
Trans-ethnic meta-analysis of blood pressure in African and European ancestriesR21HL123677 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2014 to 2015
$242k
Sex- and Smoking- Specific DNA Methylation Signatures of Central Adiposity ChangeK99HL130580 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JUSTICE, ANNE · 2016 to 2017
$217k
British Heart Foundation CH/12/2/29428British Heart Foundation RG/08/014/24067British Heart Foundation RG/14/5/30893British Heart Foundation SP/02/002/14543British Heart Foundation SP/09/002/27676European Research Council 268834Medical Research Council 1508647Medical Research Council G0800270Medical Research Council MR/L003120/1NCATS NIH HHS UL1 TR000124NHLBI NIH HHS K99 HL130580NHLBI NIH HHS R01 HL163262NHLBI NIH HHS R21 HL123677NHLBI NIH HHS T32 HL098049NIDDK NIH HHS K23 DK088942NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R56 DK104806NIEHS NIH HHS P30 ES010126NIH HHS S10 OD020069
6 · The paper itself

Abstract

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-CAD associations (P < 5 × 10

Indexed as

Genome-Wide Association StudyArteriesAtherosclerosisCell AdhesionChemotaxis, LeukocyteCoronary Artery DiseaseEnergy MetabolismFemaleGenetic Predisposition to DiseaseGenotypeHistone CodeHumansMaleMuscle, Smooth, VascularPolymorphism, Single NucleotideQuantitative Trait Loci

Identifiers

PMID28530674
PMCPMC5555387

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.