SynthesisNature genetics2017
Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence.
Erratum issuedOpen access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 228 papers, 15 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 15 pooled it
61.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
228 citing papers in PubMed, 15 syntheses or guidelines pooled it, 506 citations in OpenAlex.
- Pooled it
- Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.Biological psychiatry · 2022Pooled it
- Large-scale association study on daily weight gain in pigs reveals overlap of genetic factors for growth in humans.BMC genomics · 2022Pooled it
- Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.Human brain mapping · 2022Pooled it
- Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.Nature communications · 2021Pooled it
- Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence.Nature communications · 2020Pooled it
- The genetic architecture of the human cerebral cortex.Science (New York, N.Y.) · 2020Pooled it
- Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.American journal of human genetics · 2019Pooled it
- Genome-wide association study identifies 30 loci associated with bipolar disorder.Nature genetics · 2019Pooled it
- Genetic Markers of ADHD-Related Variations in Intracranial Volume.The American journal of psychiatry · 2019Pooled it
- Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.Nature genetics · 2019Pooled it
- Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.Molecular psychiatry · 2019Pooled it
- Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.Nature genetics · 2019Pooled it
- Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.Nature genetics · 2018Pooled it
- Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.Nature genetics · 2018Pooled it
- Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations.Human genetics · 2018Trial
- Imputation of fluid intelligence scores reduces ascertainment bias and increases power for analyses of common and rare variants.Nature genetics · 2026Article
- Article
- Convergent genetic pathways linking neuropsychiatric and ocular disorders in children.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Shared genetic architecture between ADHD and intelligence varies across ADHD subtypes.BMC medicine · 2026Article
168 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
30 authors at 11 institutions in 4 countries.
Suzanne SniekersDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
Sven StringerDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3115-8532
Kyoko WatanabeDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
Philip R JansenDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
Jonathan R I ColemanMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Eva KrapohlMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Erdogan TaskesenDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
Anke R HammerschlagDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-4847-4814
Aysu OkbayDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
Delilah ZabanehMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Gerome BreenMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
David CesariniCenter for Experimental Social Science, Department of Economics, New York University, New York, New York, USA.
Christopher F ChabrisDepartment of Psychology, Union College, Schenectady, New York, USA.
William G IaconoDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Magnus JohannessonDepartment of Economics, Stockholm School of Economics, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8759-6393
Philipp KoellingerDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
James J LeeDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID http://orcid.org/0000-0001-6547-5128
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Mike B MillerDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
William E R OllierCentre for Epidemiology, Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, UK.
Antony PaytonCentre for Epidemiology, Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, UK.
Neil PendletonDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Robert PlominMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Cornelius A RietveldErasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.
Henning TiemeierDepartment of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Danielle PosthumaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7582-2365
Amsterdam Neuroscience · NLKing's College London · GBErasmus MC · NLUniversity of Minnesota · USManchester Academic Health Science Centre · GBErasmus University Rotterdam · NLKarolinska Institutet · SELeiden University · NLNew York University · USStockholm School of Economics · SEUnion College · US
Funding
NBER Training Program in Aging and Health EconomicsT32AG000186 · NIA · NATIONAL BUREAU OF ECONOMIC RESEARCH · PI CUTLER, DAVID M, FINKELSTEIN, AMY N. · 1989 to 2024
$9.6MTWIN STUDY OF FEMALE ALCOHOLISMS AND OTHER DISORDERSR01AA009367 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 1992 to 2013
$9.0MTwin Family Study of Vulnerability to Substance AbuseR37DA005147 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2009 to 2018
$6.4MA Longitudinal Study of Adopted Youth and Their FamiliesR01MH066140 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 2003 to 2013
$5.8MTWIN/FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSER01DA005147 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G · 1987 to 2007
$5.5MAdolescent drinking and midlife outcomes: A prospective cotwin control studyR37AA009367 · NIAAA · UNIVERSITY OF MINNESOTA · PI MCGUE, MATTHEW K. · 2016 to 2024
$5.4MResearch Training: Mental Health Behavior GeneticsT32MH016880 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI Naomi P. Friedman, Matthew Charles Keller · 1985 to 2026
$5.3MTWIN STUDY OF ADHD, CD, AND SUBSTANCE ABUSER01DA013240 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G. · 2000 to 2010
$5.0MAdult consequences of youth substance use: Twin study enriched for SUD riskR01DA036216 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2013 to 2017
$3.2MInterstitial Cystitis in Swedish TwinsU01DK066134 · NIDDK · KAROLINSKA INSTITUTE · PI PEDERSEN, NANCY L · 2004 to 2008
$2.9MSIBLING MODELS OF ADOLESCENT ALCOHOL USE AND ABUSER01AA011886 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 1998 to 2008
$2.5MSubstance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentR01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2011 to 2011
$1.6MBiotechnology and Biological Sciences Research Council BB/F022441/1EPA EP-C-14-005European Research Council 647648Medical Research Council G0100594Medical Research Council G0500079Medical Research Council G0600237Medical Research Council G0900753Medical Research Council G0901245Medical Research Council G0901461Medical Research Council G19/2Medical Research Council MC_QA137853Medical Research Council MR/K002279/1Medical Research Council MR/M021475/1NIAAA NIH HHS R01 AA009367NIAAA NIH HHS R01 AA011886NIAAA NIH HHS R37 AA009367NIA NIH HHS T32 AG000186NIDA NIH HHS F31 DA029377NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA013240NIDA NIH HHS R01 DA024417NIDA NIH HHS R01 DA036216NIDA NIH HHS R37 DA005147NIDDK NIH HHS U01 DK066134NIMH NIH HHS R01 MH066140NIMH NIH HHS T32 MH016880
Abstract
Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta-analysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10
Indexed as
Genome-Wide Association StudyAdolescentAdultAgedBrainChildChild, PreschoolFemaleHumansInfantIntelligenceLinkage DisequilibriumMaleMiddle AgedNerve Tissue ProteinsPolymorphism, Single NucleotideNerve Tissue Proteins
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