Evidence map›Paper›PMID 28530549›Full record

ArticleeLife2017

A genetic basis for molecular asymmetry at vertebrate electrical synapses.

Adam C Miller, Alex C Whitebirch, Arish N Shah, Kurt C Marsden, Michael Granato, John O'Brien, Cecilia B Moens

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 52 citations in OpenAlex.

  1. Defining the electrical synapse.Nature reviews. Neuroscience · 2026
    Review
  2. Article
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  4. Article
  5. Electrical Synapses Mediate Embryonic Hyperactivity in a Zebrafish Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
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  11. Gap junction Delta-2b (Frontiers in cell and developmental biology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. The Role of GJD2(Cx36) in Refractive Error Development.Investigative ophthalmology & visual science · 2022
    Review
  16. ThemicroPublication biology · 2022
    Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Adam C MillerDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0001-7519-3677
Alex C WhitebirchDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0002-9178-1636
Arish N ShahDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.
Kurt C MarsdenDepartment of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Michael GranatoDepartment of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
John O'BrienDepartment of Ophthalmology and Visual Science, McGovern Medical School, University of Texas Health Sciences Center at Houston, Houston, United States.ORCID 0000-0002-0270-3442
Cecilia B MoensDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.
Fred Hutch Cancer Center · USUniversity of Pennsylvania · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
REGULATION OF RETINAL GAP JUNCTIONSR01EY012857 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JOHN O'BRIEN · 2000 to 2026
$8.3M
UTHouston Core Center for Vision ResearchP30EY028102 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MASSEY, STEPHEN C · 2017 to 2021
$3.1M
Cellular and molecular analysis of startle modulationR01MH109498 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2016 to 2020
$2.4M
Molecular mechanisms of electrical synapse formation in vivoR00NS085035 · NINDS · UNIVERSITY OF OREGON · PI MILLER, ADAM C · 2016 to 2018
$747k
NCI NIH HHS P30 CA015704NEI NIH HHS P30 EY028102NEI NIH HHS R01 EY012857NIMH NIH HHS R01 MH109498NINDS NIH HHS R00 NS085035
6 · The paper itself

Abstract

Neural network function is based upon the patterns and types of connections made between neurons. Neuronal synapses are adhesions specialized for communication and they come in two types, chemical and electrical. Communication at chemical synapses occurs via neurotransmitter release whereas electrical synapses utilize gap junctions for direct ionic and metabolic coupling. Electrical synapses are often viewed as symmetrical structures, with the same components making both sides of the gap junction. By contrast, we show that a broad set of electrical synapses in zebrafish,

Indexed as

Electrical SynapsesAnimalsConnexinsGap JunctionsNeuronsZebrafishConnexinsbehaviorconnexinselectrical synapseneural circuit wiringneurosciencesynaptogenesiszebrafish

Identifiers

PMID28530549
PMCPMC5462537
OpenAlexW2953269428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.