Trial reportJournal of medical screening2018
A cluster randomized trial of strategies to increase uptake amongst young women invited for their first cervical screen: The STRATEGIC trial.
Trial report in Journal of medical screening, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Identifying optimum implementation for human papillomavirus self-sampling in underserved communities: A systematic review.Journal of medical screening · 2025Pooled it
- Electronic Health Interventions and Cervical Cancer Screening: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2024Pooled it
- Components and effectiveness of patient navigation programmes to increase participation to breast, cervical and colorectal cancer screening: A systematic review.Cancer medicine · 2023Pooled it
- Offering HPV self-sampling kits: an updated meta-analysis of the effectiveness of strategies to increase participation in cervical cancer screening.British journal of cancer · 2023Pooled it
- Does self-sampling for human papilloma virus testing have the potential to increase cervical cancer screening? An updated meta-analysis of observational studies and randomized clinical trials.Frontiers in public health · 2022Pooled it
- Interventions targeted at women to encourage the uptake of cervical screening.The Cochrane database of systematic reviews · 2021Pooled it
- Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses.BMJ (Clinical research ed.) · 2018Pooled it
- Cost-effectiveness of strategies to increase cervical screening uptake at first invitation (STRATEGIC).Journal of medical screening · 2018Pooled it
- Identifying the key barriers, facilitators and factors associated with cervical cancer screening attendance in young women: A systematic review.Women's health (London, England)Pooled it
- Non-speculum sampling approaches for cervical screening in older women: randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Trial
- Preferences for interventions designed to increase cervical screening uptake in non-attending young women: How findings from a discrete choice experiment compare with observed behaviours in a trial.Health expectations : an international journal of public participation in health care and health policy · 2020Trial
- Randomised trial of HPV self-sampling among non-attenders in the Slovenian cervical screening programme ZORA: comparing three different screening approaches.Radiology and oncology · 2018Trial
- Trial
- Scoping review on navigation interventions for older adults with cancer in Europe and beyond.European geriatric medicine · 2026Review
- Utilising the COM-B model to interpret barriers and facilitators to cervical cancer screening in young women.Journal of health psychology · 2025Article
- Human Papillomavirus Self-Sampling for Unscreened Women Aged 24 Years During the COVID-19 Pandemic.Healthcare (Basel, Switzerland) · 2024Article
- Preconception health risk factors documented in general practice electronic medical records.BMJ sexual & reproductive health · 2024Article
- How do young women approaching screening age interpret the NHS cervical screening leaflet? A mixed methods study of identifying interpretation difficulties, barriers, facilitators, and leaflet interpretation, engagement and future screening behaviour.Health psychology and behavioral medicine · 2024Article
- Improving care seeking behavior toward cervical cancer screening participation among Gwafan community women, North-Central Nigeria.BMC women's health · 2023Article
- Exploring the attitudes and practices of female doctors towards cervical cancer screening in primary health care centers.Journal of medicine and life · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Objectives To measure the feasibility and effectiveness of interventions to increase cervical screening uptake amongst young women. Methods A two-phase cluster randomized trial conducted in general practices in the NHS Cervical Screening Programme. In Phase 1, women in practices randomized to intervention due for their first invitation to cervical screening received a pre-invitation leaflet and, separately, access to online booking. In Phase 2, non-attenders at six months were randomized to one of: vaginal self-sample kits sent unrequested or offered; timed appointments; nurse navigator; or the choice between nurse navigator or self-sample kits. Primary outcome was uplift in intervention vs. control practices, at 3 and 12 months post invitation. Results Phase 1 randomized 20,879 women. Neither pre-invitation leaflet nor online booking increased screening uptake by three months (18.8% pre-invitation leaflet vs. 19.2% control and 17.8% online booking vs. 17.2% control). Uptake was higher amongst human papillomavirus vaccinees at three months (OR 2.07, 95% CI 1.69-2.53, p < 0.001). Phase 2 randomized 10,126 non-attenders, with 32-34 clusters for each intervention and 100 clusters as controls. Sending self-sample kits increased uptake at 12 months (OR 1.51, 95% CI 1.20-1.91, p = 0.001), as did timed appointments (OR 1.41, 95% CI 1.14-1.74, p = 0.001). The offer of a nurse navigator, a self-sample kits on request, and choice between timed appointments and nurse navigator were ineffective. Conclusions Amongst non-attenders, self-sample kits sent and timed appointments achieved an uplift in screening over the short term; longer term impact is less certain. Prior human papillomavirus vaccination was associated with increased screening uptake.
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