ArticleNature communications2017
Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Methyltransferase-assisted single duplex sequencing for detecting circulating tumor DNA.EMBO molecular medicine · 2026Article
- MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations.Nucleic acids research · 2024Article
- Chasing Sequencing Perfection: Marching Toward Higher Accuracy and Lower Costs.Genomics, proteomics & bioinformatics · 2024Review
- Single duplex DNA sequencing with CODEC detects mutations with high sensitivity.Nature genetics · 2023Article
- Distinguishing excess mutations and increased cell death based on variant allele frequencies.PLoS computational biology · 2022Article
- Single-cell genome sequencing of protozoan parasites.Trends in parasitology · 2021Review
- Review
- Drivers of within-host genetic diversity in acute infections of viruses.PLoS pathogens · 2020Article
- High efficiency error suppression for accurate detection of low-frequency variants.Nucleic acids research · 2019Article
- ATP1A3 mosaicism in families with alternating hemiplegia of childhood.Clinical genetics · 2019Article
- Low-level parental mosaicism affects the recurrence risk of holoprosencephaly.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Detecting Rare Mutations and DNA Damage with Sequencing-Based Methods.Trends in biotechnology · 2018Review
- Genomic mosaicism in paternal sperm and multiple parental tissues in a Dravet syndrome cohort.Scientific reports · 2017Article
- Next-generation sequencing methodologies to detect low-frequency mutations: "Catch me if you can".Mutation research. Reviews in mutation researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detection of de novo, low-frequency mutations is essential for characterizing cancer genomes and heterogeneous cell populations. However, the screening capacity of current ultrasensitive NGS methods is inadequate owing to either low-efficiency read utilization or severe amplification bias. Here, we present o2n-seq, an ultrasensitive and high-efficiency NGS library preparation method for discovering de novo, low-frequency mutations. O2n-seq reduces the error rate of NGS to 10
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Registered trials
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