Evidence map›Paper›PMID 28530125›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans.

David R Owen, Nehal Narayan, Lisa Wells, Luke Healy, Erica Smyth, Eugenii A Rabiner, Dylan Galloway, John B Williams, Joshua Lehr, Harpreet Mandhair and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 8 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 8 syntheses or guidelines pooled it, 194 citations in OpenAlex.

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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

David R Owen1 Division of Brain Sciences, Department of Medicine Hammersmith Hospital, Imperial College London, London, UK.
Nehal Narayan2 Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK.
Lisa Wells3 Imanova Centre for Imaging Science, Hammersmith Hospital, London, UK.
Luke Healy4 Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Erica Smyth3 Imanova Centre for Imaging Science, Hammersmith Hospital, London, UK.
Eugenii A Rabiner3 Imanova Centre for Imaging Science, Hammersmith Hospital, London, UK.
Dylan Galloway6 Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland.
John B Williams6 Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland.
Joshua Lehr6 Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland.
Harpreet Mandhair2 Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK.
Laura An Peferoen7 Pathology Department, VU Medical Centre, VU University of Amsterdam, The Netherlands.
Peter C Taylor2 Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK.
Sandra Amor7 Pathology Department, VU Medical Centre, VU University of Amsterdam, The Netherlands.
Jack P Antel4 Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Paul M Matthews1 Division of Brain Sciences, Department of Medicine Hammersmith Hospital, Imperial College London, London, UK.
Craig S Moore6 Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland.
Hammersmith Hospital · GBMemorial University of Newfoundland · CANuffield Orthopaedic Centre · GBKing's College London · GBMcGill University · CAMontreal Neurological Institute and Hospital · CAQueen Mary University of London · GBUniversity of Amsterdam · NL

Funding

Medical Research Council G0900897Medical Research Council MR/N008219/1Medical Research Council MR/N026934/1
6 · The paper itself

Abstract

The 18kDa Translocator Protein (TSPO) is the most commonly used tissue-specific marker of inflammation in positron emission tomography (PET) studies. It is expressed in myeloid cells such as microglia and macrophages, and in rodent myeloid cells expression increases with cellular activation. We assessed the effect of myeloid cell activation on TSPO gene expression in both primary human and rodent microglia and macrophages in vitro, and also measured TSPO radioligand binding with

Indexed as

AcetamidesAdultAnimalsBrainCells, CulturedGene ExpressionGranulocyte-Macrophage Colony-Stimulating FactorHumansInterferon-gammaLipopolysaccharidesMacrophagesMice, Inbred C57BLMicrogliaMiddle AgedMyeloid CellsProtein BindingAcetamidesBzrp protein, mouseGranulocyte-Macrophage Colony-Stimulating FactorInterferon-gammaLipopolysaccharidesN-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamidePyridinesReceptors, GABATSPO protein, humaninflammationmacrophagesmicroglianeurodegenerationPositron emission tomography

Identifiers

PMID28530125
PMCPMC5536262
OpenAlexW2619298813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.