Evidence map›Paper›PMID 28530042›Full record

ArticleJournal of the International AIDS Society2017

Growing up with perinatal HIV: changes in clinical outcomes before and after transfer to adult care in the UK.

Ali Judd, Intira Jeannie Collins, Francesca Parrott, Teresa Hill, Sophie Jose, Deborah Ford, Hibo Asad, Diana M Gibb, Caroline Sabin

Open access · goldAbstract read
In one paragraph

Article in Journal of the International AIDS Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Evolution of CD4 T-Cell Count With Age in a Cohort of Young People Growing Up With Perinatally Acquired Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Healthcare Transition Outcomes Among Young Adults With Perinatally Acquired Human Immunodeficiency Virus Infection in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  11. Peritransition Outcomes of Southeast Asian Adolescents and Young Adults With HIV Transferring From Pediatric to Adult Care.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Cancer in adolescents and young adults living with HIV.Current opinion in HIV and AIDS · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ali JuddMRC Clinical Trials Unit, University College London (UCL), UCL, London, UK.
Intira Jeannie CollinsMRC Clinical Trials Unit, University College London (UCL), UCL, London, UK.
Francesca ParrottMRC Clinical Trials Unit, University College London (UCL), UCL, London, UK.
Teresa HillMRC Clinical Trials Unit, University College London (UCL), UCL, London, UK.
Sophie JoseResearch Department of Infection and Population Health, UCL, London, UK.
Deborah FordMRC Clinical Trials Unit, University College London (UCL), UCL, London, UK.
Hibo AsadMRC Clinical Trials Unit, University College London (UCL), UCL, London, UK.
Diana M GibbMRC Clinical Trials Unit, University College London (UCL), UCL, London, UK.
Caroline SabinResearch Department of Infection and Population Health, UCL, London, UK.
University College London · GBMRC Clinical Trials Unit at UCL · GB

Funding

Medical Research Council G0600337Medical Research Council G0900274Medical Research Council MC_UU_12023/17Medical Research Council MC_UU_12023/26Medical Research Council MR/M004236/1
6 · The paper itself

Abstract

introductionWith improved survival, adolescents with perinatal HIV (PHIV) are transitioning from paediatric to adult care, but there are few published data on clinical outcomes post-transfer. Using linked data from patients in the national UK/Ireland paediatric cohort (CHIPS) and an adult UK cohort of outpatient clinics (UK CHIC), we describe mortality and changes in immunological status post-transfer.

methodsParticipants in CHIPS aged ≥13 years by the end of 2013 were linked to the UK CHIC database. Mixed effects models explored changes in CD4 count before and after transfer, including interactions between time and variables where interaction

resultsOf 1,215 paediatric participants aged ≥13 years, 271 (22%) had linked data in UK CHIC. One hundred and forty-six (53%) were female, median age at last visit in paediatric care was 17 [interquartile range, IQR 16,18] years, median duration in paediatric care was 11.8 [6.6,15.5] years, and in adult care was 2.9 [1.5,5.9] years. At last visit in paediatric care, 74% (

conclusionsOur findings suggest that CD4 in adolescents with perinatal HIV in the UK was declining in the period before transition to adult care, and there was some reversal in this trend post-transfer in some groups. Across the transition period, CD4 was higher in those with later birth years, suggesting improvements in clinical care and/or transition planning over time.

Indexed as

Transition to Adult CareAdolescentCD4 Lymphocyte CountCohort StudiesFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalIrelandMaleTreatment OutcomeUnited KingdomViral LoadYoung Adultadolescentadult careHIVpaediatricperinataltransfertransitionUnited Kingdomyoung person

Identifiers

PMID28530042
PMCPMC5577702
OpenAlexW2615908530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.