Evidence map›Paper›PMID 28530032›Full record

ArticleJournal of the International AIDS Society2017

HCV Ag quantification as a one-step procedure in diagnosing chronic hepatitis C infection in Cameroon: the ANRS 12336 study.

Léa Duchesne, Richard Njouom, Frédéric Lissock, Gishlaine Flore Tamko-Mella, Sandrine Rallier, Lila Poiteau, Alexandre Soulier, Stéphane Chevaliez, Guy Vernet, Nicolas Rouveau and 3 more

Open access · goldAbstract readValidation Study
In one paragraph

Article in Journal of the International AIDS Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Biomarkers in Detection of Hepatitis C Virus Infection.Pathogens (Basel, Switzerland) · 2024
    Review
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  8. Article
  9. Article
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  12. Article
  13. Hepatitis C Continuum of Care in a Treatment Center in Sub-Saharan Africa.Journal of clinical and experimental hepatology · 2018
    Article
  14. Article
  15. Article
  16. Approaches for simplified HCV diagnostic algorithms.Journal of the International AIDS Society · 2018
    Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Léa DuchesneInstitut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), Sorbonne Universités, UPMC Univ Paris 06, Inserm, Paris, France.
Richard NjouomVirology Department, Pasteur Center of Cameroun, Yaoundé, Cameroon.
Frédéric LissockVirology Department, Pasteur Center of Cameroun, Yaoundé, Cameroon.
Gishlaine Flore Tamko-MellaVirology Department, Pasteur Center of Cameroun, Yaoundé, Cameroon.
Sandrine RallierNational Reference Center for Viral Hepatitis B, C and delta, Department of Virology, Hôpital Henri Mondor, Inserm U955, Université Paris-Est, Créteil, France.
Lila PoiteauNational Reference Center for Viral Hepatitis B, C and delta, Department of Virology, Hôpital Henri Mondor, Inserm U955, Université Paris-Est, Créteil, France.
Alexandre SoulierNational Reference Center for Viral Hepatitis B, C and delta, Department of Virology, Hôpital Henri Mondor, Inserm U955, Université Paris-Est, Créteil, France.
Stéphane ChevaliezNational Reference Center for Viral Hepatitis B, C and delta, Department of Virology, Hôpital Henri Mondor, Inserm U955, Université Paris-Est, Créteil, France.
Guy VernetVirology Department, Pasteur Center of Cameroun, Yaoundé, Cameroon.
Nicolas Rouveau"Research in Resource-Limited Settings" Department, ANRS, Paris, France.
Jean-Michel PawlotskyNational Reference Center for Viral Hepatitis B, C and delta, Department of Virology, Hôpital Henri Mondor, Inserm U955, Université Paris-Est, Créteil, France.
Pierre-Marie GirardInstitut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), Sorbonne Universités, UPMC Univ Paris 06, Inserm, Paris, France.
Karine LacombeInstitut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), Sorbonne Universités, UPMC Univ Paris 06, Inserm, Paris, France.
Centre Pasteur du Cameroun · CMDepartment of Virology · FRAssistance Publique – Hôpitaux de Paris · FRInserm · FRSorbonne Université · FRUniversité Paris-Est Créteil · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe diagnostic procedure for chronic hepatitis C infection (CHC) usually combines anti-HCV antibody (HCV-

methodsThe cAg was quantified by an automated assay (Abbott Diagnostics) in 465 HCV-

resultsAmong the 465 HCV-

conclusionsThe cAg quantification displayed a high specificity and sensitivity for the diagnosis of CHC in Cameroon, and its performance was not significantly modified by a concomitant HIV or HBV infection. In the context of CHC elimination on a global scale, using cAg quantification as a screening tool to directly identify CHC could be a reliable tool in a "test and treat" strategy.

Indexed as

AdultAgedCameroonCoinfectionCross-Sectional StudiesFemaleHepatitis BHepatitis C AntibodiesHepatitis C AntigensHepatitis C, ChronicHIV InfectionsHumansMaleMiddle AgedROC CurveSensitivity and SpecificityHepatitis C AntibodiesHepatitis C Antigenschronic hepatitis Cco-infectiondiagnosisHCV core antigenhepatitis B virusHIVSub-Saharan Africa

Identifiers

PMID28530032
PMCPMC5515056
OpenAlexW2616855471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.