Evidence map›Paper›PMID 28529928›Full record

ArticleFrontiers in cellular and infection microbiology2017

The Probiotic Compound VSL#3 Modulates Mucosal, Peripheral, and Systemic Immunity Following Murine Broad-Spectrum Antibiotic Treatment.

Ira Ekmekciu, Eliane von Klitzing, Ulrike Fiebiger, Christian Neumann, Petra Bacher, Alexander Scheffold, Stefan Bereswill, Markus M Heimesaat

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 63 citations in OpenAlex.

  1. The potential ofiScience · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Gut Commensal Antibiotic-ResistantResearch (Washington, D.C.) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The negative effect ofFrontiers in microbiology · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. PasteurizedAmerican journal of physiology. Endocrinology and metabolism · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ira EkmekciuGastrointestinal Microbiology Research Group, Department of Microbiology and Hygiene, Institute for Microbiology and Hygiene, Charité - University MedicineBerlin, Germany.
Eliane von KlitzingGastrointestinal Microbiology Research Group, Department of Microbiology and Hygiene, Institute for Microbiology and Hygiene, Charité - University MedicineBerlin, Germany.
Ulrike FiebigerGastrointestinal Microbiology Research Group, Department of Microbiology and Hygiene, Institute for Microbiology and Hygiene, Charité - University MedicineBerlin, Germany.
Christian NeumannDepartment of Cellular Immunology, Clinic for Rheumatology and Clinical Immunology, Charité - University MedicineBerlin, Germany.
Petra BacherDepartment of Cellular Immunology, Clinic for Rheumatology and Clinical Immunology, Charité - University MedicineBerlin, Germany.
Alexander ScheffoldDepartment of Cellular Immunology, Clinic for Rheumatology and Clinical Immunology, Charité - University MedicineBerlin, Germany.
Stefan BereswillGastrointestinal Microbiology Research Group, Department of Microbiology and Hygiene, Institute for Microbiology and Hygiene, Charité - University MedicineBerlin, Germany.
Markus M HeimesaatGastrointestinal Microbiology Research Group, Department of Microbiology and Hygiene, Institute for Microbiology and Hygiene, Charité - University MedicineBerlin, Germany.
Institute of Medical Microbiology and Hygiene · DECharité - Universitätsmedizin Berlin · DEGerman Rheumatism Research Centre · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is compelling evidence linking the commensal intestinal microbiota with host health and, in turn, antibiotic induced perturbations of microbiota composition with distinct pathologies. Despite the attractiveness of probiotic therapy as a tool to beneficially alter the intestinal microbiota, its immunological effects are still incompletely understood. The aim of the present study was to assess the efficacy of the probiotic formulation VSL#3 consisting of eight distinct bacterial species (including

Indexed as

Adaptive ImmunityAnimalsAnti-Bacterial AgentsBacteriaB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesColonCytokinesDendritic CellsDrug CombinationsFecesFemaleGastrointestinal MicrobiomeImmunity, InnateImmunohistochemistryAnti-Bacterial AgentsCytokinesDrug Combinationsantibioticsfecal microbiota transplantationinnate and adaptive immunitymicrobiotamucosal and peripheral and central immunityprobioticssecondary abiotic (gnotobiotic) mice

Identifiers

PMID28529928
PMCPMC5418240
OpenAlexW2611036233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.