ArticleNeuroImage. Clinical2017
The dynamics of functional connectivity in neocortical focal epilepsy.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A Wavelet-Based Framework for Mapping Long Memory in Resting-State fMRI: Age-Related Changes in the Hippocampus From the ADHD-200 Dataset.Human brain mapping · 2026Article
- Thalamic organization differentially contributes to clinical conditions in epilepsy.Communications medicine · 2026Article
- Motor and default mode network states of rest in frontal lobe epilepsy.Neuroimage. Reports · 2025Article
- Cross-sectional and longitudinal changes in category selectivity in visual cortex following pediatric cortical resection.Communications biology · 2025Article
- DySCo: A general framework for dynamic functional connectivity.PLoS computational biology · 2025Article
- Review
- Hub disruption in HIV disease and cocaine use: A connectomics analysis of brain function.Drug and alcohol dependence · 2024Article
- On the Spatial Distribution of Temporal Complexity in Resting State and Task Functional MRI.Entropy (Basel, Switzerland) · 2022Article
- Characterization of the Functional Dynamics in the Neonatal Brain during REM and NREM Sleep States by means of Microstate Analysis.Brain topography · 2021Article
- Aberrant Dynamics of Regional Coherence Measured by Resting-State fMRI in Children With Benign Epilepsy With Centrotemporal Spikes (BECTS).Frontiers in neurology · 2021Article
- Prediction of Seizure Recurrence. A Note of Caution.Frontiers in neurology · 2021Article
- Abnormal Static and Dynamic Functional Connectivity in Left and Right Temporal Lobe Epilepsy.Frontiers in neuroscience · 2021Article
- Dynamical Mechanisms of Interictal Resting-State Functional Connectivity in Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Altered Functional Connectivity after Epileptic Seizure Revealed by Scalp EEG.Neural plasticity · 2020Article
- A cross-disorder connectome landscape of brain dysconnectivity.Nature reviews. Neuroscience · 2019Review
- Optimization of surgical intervention outside the epileptogenic zone in the Virtual Epileptic Patient (VEP).PLoS computational biology · 2019Article
- Identification of epileptic brain states by dynamic functional connectivity analysis of simultaneous EEG-fMRI: a dictionary learning approach.Scientific reports · 2019Article
- Localization of Epileptogenic Zone With the Correction of Pathological Networks.Frontiers in neurology · 2018Article
- Dynamic coupling between fMRI local connectivity and interictal EEG in focal epilepsy: A wavelet analysis approach.Human brain mapping · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Focal epilepsy is characterised by paroxysmal events, reflecting changes in underlying local brain networks. To capture brain network activity at the maximal temporal resolution of the acquired functional magnetic resonance imaging (fMRI) data, we have previously developed a novel analysis framework called Dynamic Regional Phase Synchrony (DRePS). DRePS measures instantaneous mean phase coherence within neighbourhoods of brain voxels. We use it here to examine how the dynamics of the functional connections of regional brain networks are altered in neocortical focal epilepsy. Using task-free fMRI data from 21 subjects with focal epilepsy and 21 healthy controls, we calculated the power spectral density of DRePS, which is a measure of signal variability in local connectivity estimates. Whole-brain averaged power spectral density of DRePS, or signal variability of local connectivity, was significantly higher in epilepsy subjects compared to healthy controls. Maximal increase in DRePS spectral power was seen in bilateral inferior frontal cortices, ipsilateral mid-cingulate gyrus, superior temporal gyrus, caudate head, and contralateral cerebellum. Our results provide further evidence of common brain abnormalities across people with focal epilepsy. We postulate that dynamic changes in specific cortical brain areas may help maintain brain function in the presence of pathological epileptiform network activity in neocortical focal epilepsy.
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