ArticleNeuroImage. Clinical2017
Symptom-specific amygdala hyperactivity modulates motor control network in conversion disorder.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07059325 (Accelerated, Left Prefrontal Transcranial Magnetic Stimulation for Functional Seizures; An Open-Label Exploration of Feasibility, Tolerability, and Preliminary Efficacy), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Accelerated, Left Prefrontal Transcranial Magnetic Stimulation for Functional Seizures; An Open-Label Exploration of Feasibility, Tolerability, and Preliminary Efficacy
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Structural alterations in functional neurological disorder and related conditions: a software and hardware problem?NeuroImage. Clinical · 2019Pooled it
- Multimodal assessment of clinical and neural changes following multidisciplinary management in functional motor disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2026Observational
- Functional and Structural Brain Imaging Correlates of Treatment Response in Functional Movement Disorder.Current neurology and neuroscience reports · 2026Review
- Ultra-high field brain MRI for functional neurological disorder: opportunities and challenges.NeuroImage. Clinical · 2026Review
- Functional Movement Disorder: Evolving Mechanisms, Diagnostic Precision, and Personalized Multidisciplinary Care.Movement disorders clinical practice · 2025Review
- Functional Neurologic Disorder,Neurology · 2024Article
- Motor actions across psychiatric disorders: A research domain criteria (RDoC) perspective.Clinical psychology review · 2024Review
- Beta-band power modulation in the human amygdala differentiates between go/no-go responses in an arm-reaching task.Journal of neural engineering · 2024Article
- Your brain on art, nature, and meditation: a pilot neuroimaging study.Frontiers in human neuroscience · 2024Article
- Transient resting-state salience-limbic co-activation patterns in functional neurological disorders.NeuroImage. Clinical · 2024Article
- The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics.Translational psychiatry · 2023Review
- Classification of Functional Movement Disorders with Resting-State Functional Magnetic Resonance Imaging.Brain connectivity · 2023Article
- A new science of emotion: implications for functional neurological disorder.Brain : a journal of neurology · 2022Review
- Functional seizures are associated with cerebrovascular disease and functional stroke is more common in patients with functional seizures than epileptic seizures.Epilepsy & behavior : E&B · 2022Article
- Identification of Prefrontal Cortex and Amygdala Expressed Genes Associated With Sevoflurane Anesthesia on Non-human Primate.Frontiers in integrative neuroscience · 2022Article
- A dimensional approach to functional movement disorders: Heresy or opportunity.Neuroscience and biobehavioral reviews · 2021Review
- Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder.Molecular psychiatry · 2021Article
- Magnetic resonance imaging histogram analysis of corpus callosum in a functional neurological disorderTurkish journal of medical sciences · 2021Article
- Reduced limbic microstructural integrity in functional neurological disorder.Psychological medicine · 2021Article
- Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda.NeuroImage. Clinical · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Initial historical accounts as well as recent data suggest that emotion processing is dysfunctional in conversion disorder patients and that this alteration may be the pathomechanistic neurocognitive basis for symptoms in conversion disorder. However, to date evidence of direct interaction of altered negative emotion processing with motor control networks in conversion disorder is still lacking. To specifically study the neural correlates of emotion processing interacting with motor networks we used a task combining emotional and sensorimotor stimuli both separately as well as simultaneously during functional magnetic resonance imaging in a well characterized group of 13 conversion disorder patients with functional hemiparesis and 19 demographically matched healthy controls. We performed voxelwise statistical parametrical mapping for a priori regions of interest within emotion processing and motor control networks. Psychophysiological interaction (PPI) was used to test altered functional connectivity of emotion and motor control networks. Only during simultaneous emotional stimulation and passive movement of the affected hand patients displayed left amygdala hyperactivity. PPI revealed increased functional connectivity in patients between the left amygdala and the (pre-)supplemental motor area and the subthalamic nucleus, key regions within the motor control network. These findings suggest a novel mechanistic direct link between dysregulated emotion processing and motor control circuitry in conversion disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.