ReviewJournal of bone and joint infection2017
Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery.
Review in Journal of bone and joint infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04238923 (Topical Gentamicin and Vancomycin for Surgical Site Infection Prophylaxis in Patients Undergoing High-Risk Vascular Surgery), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Topical Gentamicin and Vancomycin for Surgical Site Infection Prophylaxis in Patients Undergoing High-Risk Vascular Surgery
Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Only a partial shield: local vancomycin postpones but does not prevent hip and knee prosthetic infections.Archives of orthopaedic and trauma surgery · 2026Article
- Clinical Outcomes of Vancomycin Powder for Surgical Site Prophylaxis in Orthopedic Surgeries: A Comparative Study.Cureus · 2025Article
- Simple Intraoperative Method for Administration of Local Antibiotic Powder in Orthopaedic Surgery.Arthroscopy techniques · 2025Article
- Clinical Characteristics of 96 Patients Presenting With Hematogenous Spinal Osteomyelitis- a Retrospective Study.Global spine journal · 2025Article
- Article
- Preventive strategies to reduce the rate of periprosthetic infections in total joint arthroplasty; a comprehensive review.Archives of orthopaedic and trauma surgery · 2024Review
- Effectiveness of combined local therapy with antibiotics and fibrin vs. vacuum-assisted wound therapy in soft tissue infections: a retrospective study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Article
- Article
- Soaking ACL grafts in vancomycin solution (1 mg/ml) reduces the infection rate without increasing the risk for re-rupture and arthrofibrosis.Archives of orthopaedic and trauma surgery · 2022Article
- Antibacterial hydrogel coating in joint mega-prosthesis: results of a comparative series.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021Article
- Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols.Materials (Basel, Switzerland) · 2021Article
- Infection after primary total knee arthroplasty: a randomized controlled prospective study of the addition of antibiotics to bone cement.Revista brasileira de ortopedia · 2021Article
- Article
- Evidence-Based Recommendations for Local Antimicrobial Strategies and Dead Space Management in Fracture-Related Infection.Journal of orthopaedic trauma · 2020Review
- Is Implant Coating With Tyrosol- and Antibiotic-loaded Hydrogel Effective in Reducing Cutibacterium (Propionibacterium) acnes Biofilm Formation? A Preliminary In Vitro Study.Clinical orthopaedics and related research · 2019Article
- Impact of Gentamicin-Loaded Bone Graft on Defect Healing in a Sheep Model.Materials (Basel, Switzerland) · 2019Article
- [Bone substitute materials as local drug carriers : Current status of substitutes of various origins].Der Orthopade · 2018Review
- [Local antibiotic therapy].Der Unfallchirurg · 2017Review
- Local Antimicrobial Treatment in Orthopaedic Surgery.Journal of bone and joint infection · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical site infection (SSI) is one of the most common complications after orthopaedic surgery, leading to significant morbidity and its associated costs. Surgical guidelines strongly recommend the use of systemic antibiotic prophylaxis to reduce the risk for developing SSI. Locally administered powdered antibiotics have the potential to provide remarkably high intra-wound concentrations without risk for systemic toxicity. However, a paucity of high quality evidence in the orthopaedic literature has prevented widespread adoption of this technique. The majority of clinical studies on local intra-wound antibiotics have evaluated the use of topical powdered vancomycin in spinal surgery, though only a single prospective study currently exists. This review will discuss all the available evidence describing the effectiveness, pharmacokinetics, and potential adverse effects with the use of topical powdered antibiotics in orthopedic surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.