ReviewJournal of bone and joint infection2017
Use of Chlorhexidine Preparations in Total Joint Arthroplasty.
Review in Journal of bone and joint infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03551561 (Antisepsis Techniques in Orthopedic Surgical Procedures), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antisepsis Techniques in Orthopedic Surgical Procedures: a Comparative Study
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Pooled it
- [Recommendations for perioperative skin care in total joint arthroplasty: antimicrobial wash lotion, precleaning and hair removal].Orthopadie (Heidelberg, Germany) · 2025Pooled it
- Research progress on debridement, antibiotics, and implant retention (DAIR) for the treatment of periprosthetic joint infection after artificial joint replacement.Archives of orthopaedic and trauma surgery · 2026Review
- Povidone iodine demonstrates strong efficacy in reducing Candida biofilm in an in vitro fungal prosthetic infection.Scientific reports · 2026Article
- Tactical use of irrigants in open orthopaedic procedures: 'what to use & when'.EFORT open reviews · 2026Review
- Effectiveness of intra-articular vancomycin in preventing prosthetic joint infections in hip and knee arthroplasty: A systematic review and meta-analysis of RCT's.Journal of orthopaedics · 2025Review
- 'Hybrid' spacers in two-stage total hip arthroplasty revision: surgical technique, clinical and radiographic outcomes.Archives of orthopaedic and trauma surgery · 2025Article
- Periprosthetic joint infections: state-of-the-art.Archives of orthopaedic and trauma surgery · 2024Review
- Article
- Comparing 0.05% chlorhexidine gluconate monotherapy to conventional antibiotic irrigation inTranslational andrology and urology · 2024Article
- Does hydrogen peroxide help mitigate the incidence ofNorth American Spine Society journal · 2024Article
- Effect of amoxicillin and clindamycin on the gene expression of markers involved in osteoblast physiology.Journal of dental sciences · 2024Article
- Effect of Commercially Available Wound Irrigation Solutions on Uninfected Host Tissue in a Murine Model.Arthroplasty today · 2024Article
- Functional Outcome of Above-Knee Amputation After Infected Total Knee Arthroplasty.Arthroplasty today · 2023Article
- Evaluation of the role of povidone‑iodine in the prevention of surgical site infections.Surgery open science · 2023Review
- Effective Biofilm Eradication on Orthopedic Implants with Methylene Blue Based Antimicrobial Photodynamic Therapy In Vitro.Antibiotics (Basel, Switzerland) · 2023Article
- 'Tis Time 'Tis Time: The Importance of Operative Time, Thoroughness, and Shakespeare in Dair Procedures in Total Joint Arthroplasty.The Iowa orthopaedic journal · 2023Article
- Do patients need advice and information to prevent infections - results of a single centre structured survey.Infection prevention in practice · 2022Article
- Common Wound Irrigation Solutions Produce Different Responses in Infected vs Sterile Host Tissue: Murine Air Pouch Infection Model.Arthroplasty today · 2022Article
- Current treatments for biofilm-associated periprosthetic joint infection and new potential strategies.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prosthetic joint infection (PJI) is a serious complication after total joint arthroplasty (TJA). Chlorhexidine is a widely used antiseptic because of its rapid and persistent action. It is well tolerated and available in different formulations at various concentrations. Chlorhexidine can be used for pre-operative skin cleansing, surgical site preparation, hand antisepsis of the surgical team and intra-articular irrigation of infected joints. The optimal intra-articular concentration of chlorhexidine gluconate in irrigation solution is 2%, to provide a persistent decrease in biofilm formation, though cytotoxicity might be an issue. Although chlorhexidine is relatively cheap, routine use of chlorhexidine without evidence of clear benefits can lead to unnecessary costs, adverse effects and even emergence of resistance. This review focuses on the current applications of various chlorhexidine formulations in TJA. As the treatment of PJI is challenging and expensive, effective preparations of chlorhexidine could help in the prevention and control of PJI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.