ReviewNeural plasticity2017
Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder.
Review in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Physical Activity as a Predictor of Clinical Trial Outcomes in Bipolar Depression: A Subanalysis of a Mitochondrial-Enhancing Nutraceutical Randomized Controlled Trial.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Trial
- Exercise (Wheel-Running) Reduces Chronic Alcohol-Induced Escalation of Drinking in Mice via Elevated BDNF-TrkB Receptor Activity.Research square · 2026Article
- Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety viaGut microbes · 2025Article
- The effect of physical activity on resilience of Chinese children: the chain mediating effect of executive function and emotional regulation.BMC pediatrics · 2025Article
- Interaction of the Vagus Nerve and Serotonin in the Gut-Brain Axis.International journal of molecular sciences · 2025Review
- Mechanisms of the effect of gut microbes on depression through the microbiota-gut-brain axis.Frontiers in nutrition · 2025Review
- Childhood Maltreatment and Internet Addiction: A Moderated Mediation Model of Depression and Physical Activities.Psychology research and behavior management · 2025Article
- Article
- Effects of Exercise on Functional Recovery in Patients with Bipolar Depression: A Study Protocol for a Randomized Controlled Trial.Metabolites · 2023Article
- Article
- Genetic and epigenetic factors associated with depression: An updated overview.Saudi journal of biological sciences · 2022Review
- Molecular Mechanisms of Exercise and Healthspan.Cells · 2022Review
- Therapeutic Interventions to Mitigate Mitochondrial Dysfunction and Oxidative Stress-Induced Damage in Patients with Bipolar Disorder.International journal of molecular sciences · 2022Review
- Effect of online aerobic exercise training in patients with bipolar depression: Protocol of a randomized clinical trial.Frontiers in psychiatry · 2022Article
- Association between circadian activity rhythms and mood episode relapse in bipolar disorder: a 12-month prospective cohort study.Translational psychiatry · 2021Article
- Neuroplasticity Improves Bipolar Disorder: A Review.Cureus · 2020Review
- Lessons Learned From a Physical Activity Intervention in Psychiatric Treatment: Patient, Staff, and Leader Perspectives.Frontiers in psychiatry · 2020Article
- Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program.Frontiers in psychiatry · 2020Article
- Preserving Mobility in Older Adults with Physical Frailty and Sarcopenia: Opportunities, Challenges, and Recommendations for Physical Activity Interventions.Clinical interventions in aging · 2020Review
- Physical Exercise and Neuroinflammation in Major Depressive Disorder.Molecular neurobiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the means by which various therapeutics mitigate them. Of those therapeutics being investigated, physical activity (PA) has shown clear and consistent promise. Accordingly, the aims of this review are to (1) explicate key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs; (2) explore the putative mechanisms by which PA mitigates these features; (3) review protocols used to induce the positive effects of PA in MDs; and (4) highlight implications for clinicians and researchers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.