Evidence map›Paper›PMID 28529632›Full record

ArticleTheranostics2017

Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors - a Triple Tracer Comparative Approach.

Rudolf A Werner, Alexander Weich, Takahiro Higuchi, Jan S Schmid, Andreas Schirbel, Michael Lassmann, Vanessa Wild, Martina Rudelius, Theodor Kudlich, Ken Herrmann and 5 more

Open access · goldAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Functional pituitary adenoma imaging.Reviews in endocrine & metabolic disorders · 2026
    Review
  3. Exploration of Chemokine Receptor 4 Targeted [Molecular imaging and biology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Research process of PET tracers for neuroendocrine tumors diagnosis.American journal of nuclear medicine and molecular imaging · 2025
    Review
  10. Article
  11. Review
  12. CXCR4-directed PET/CT with [European journal of nuclear medicine and molecular imaging · 2024
    Article
  13. Article
  14. Advances in PET Imaging of the CXCR4 Receptor: [Seminars in nuclear medicine · 2024
    Review
  15. Review
  16. Review
  17. Article
  18. [European journal of nuclear medicine and molecular imaging · 2023
    Article
  19. Review
  20. CXCR4-targeted theranostics in oncology.European journal of nuclear medicine and molecular imaging · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Rudolf A WernerDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Alexander WeichDepartment of Internal Medicine II, Gastroenterology, University Hospital Würzburg, Würzburg, Germany.
Takahiro HiguchiDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Jan S SchmidDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Andreas SchirbelDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Michael LassmannDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Vanessa WildInstitute for Pathology, University of Würzburg, Würzburg, Germany.
Martina RudeliusComprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würz-burg, Germany.
Theodor KudlichDepartment of Internal Medicine II, Gastroenterology, University Hospital Würzburg, Würzburg, Germany.
Ken HerrmannDepartment of Nuclear Medicine, University Hospital Essen, Essen, Germany.
Michael ScheurlenDepartment of Internal Medicine II, Gastroenterology, University Hospital Würzburg, Würzburg, Germany.
Andreas K BuckDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Saskia KropfScintomics GmbH, Fürstenfeldbruck, Germany.
Hans-Jürgen WesterPharmaceutical Radiochemistry, Technische Universität München, Munich, Germany.
Constantin LapaDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Universitätsklinikum Würzburg · DEComprehensive Cancer Center Mainfranken · DEUniversity of Würzburg · DEEssen University Hospital · DETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

C-X-C motif chemokine receptor 4 (CXCR4) and somatostatin receptors (SSTR) are overexpressed in gastro-entero-pancreatic neuroendocrine tumors (GEP-NET). In this study, we aimed to elucidate the feasibility of non-invasive CXCR4 positron emission tomography/computed tomography (PET/CT) imaging in GEP-NET patients using [

Indexed as

AgedAged, 80 and overFemaleFluorine RadioisotopesGallium RadioisotopesHumansMaleMiddle AgedNeoplasm GradingNeuroendocrine TumorsPositron Emission Tomography Computed TomographyRadiopharmaceuticalsReceptors, CXCR4Staining and LabelingCXCR4 protein, humanFluorine-18Fluorine RadioisotopesGallium-68Gallium RadioisotopesRadiopharmaceuticalsReceptors, CXCR4[68Ga]Pentixaforchemokine receptorCXCR4DOTATOCNeuroendocrine tumorpeptide receptor radionuclide therapy.PET/CTPRRTSSTR

Identifiers

PMID28529632
PMCPMC5436508
OpenAlexW2604539141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.