Evidence map›Paper›PMID 28529477›Full record

ArticleFrontiers in neuroanatomy2017

Prox1 Is a Marker for AII Amacrine Cells in the Mouse Retina.

Luis Pérez de Sevilla Müller, Shaghauyegh S Azar, Janira de Los Santos, Nicholas C Brecha

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroanatomy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

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  7. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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  17. Review
  18. Mouse Retinal Cell Atlas: Molecular Identification of over Sixty Amacrine Cell Types.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Luis Pérez de Sevilla MüllerDepartments of Neurobiology, Medicine and Ophthalmology, David Geffen School of Medicine at Los Angeles, University of California, Los AngelesLos Angeles, CA, USA.
Shaghauyegh S AzarDepartments of Neurobiology, Medicine and Ophthalmology, David Geffen School of Medicine at Los Angeles, University of California, Los AngelesLos Angeles, CA, USA.
Janira de Los SantosDepartments of Neurobiology, Medicine and Ophthalmology, David Geffen School of Medicine at Los Angeles, University of California, Los AngelesLos Angeles, CA, USA.
Nicholas C BrechaDepartments of Neurobiology, Medicine and Ophthalmology, David Geffen School of Medicine at Los Angeles, University of California, Los AngelesLos Angeles, CA, USA.
University of California, Los Angeles · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
NEUROCHEMICAL PATHWAYS IN THE INNER RETINAR01EY004067 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRECHA, NICHOLAS C. · 1985 to 2019
$9.0M
Regulation of Calcium Signaling in Retinal Ganglion Cells after Nerve InjuryI01BX000764 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI BRECHA, NICHOLAS C. · 2011 to 2020
–
BLRD VA I01 BX000764BLRD VA IK6 BX005230NEI NIH HHS R01 EY004067NIDDK NIH HHS P30 DK041301
6 · The paper itself

Abstract

The transcription factor Prox1 is expressed in multiple cells in the retina during eye development. This study has focused on neuronal Prox1 expression in the inner nuclear layer (INL) of the adult mouse retina. Prox1 immunostaining was evaluated in vertical retinal sections and whole mount preparations using a specific antibody directed to the C-terminus of Prox1. Strong immunostaining was observed in numerous amacrine cell bodies and in all horizontal cell bodies in the proximal and distal INL, respectively. Some bipolar cells were also weakly immunostained. Prox1-immunoreactive amacrine cells expressed glycine, and they formed 35 ± 3% of all glycinergic amacrine cells. Intracellular Neurobiotin injections into AII amacrine cells showed that all gap junction-coupled AII amacrine cells express Prox1, and no other Prox1-immunostained amacrine cells were in the immediate area surrounding the injected AII amacrine cell. Prox1-immunoreactive amacrine cell bodies were distributed across the retina, with their highest density (3887 ± 160 cells/mm

Indexed as

AII amacrine cellsglycinemouse retinaProx1transcription factorvision

Identifiers

PMID28529477
PMCPMC5418924
OpenAlexW2610858055

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.