ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2017
Risk Factors for Depression: Differential Across Age?
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology of depressive disorders in people living with hypertension in Africa: a systematic review and meta-analysis.BMJ open · 2020Pooled it
- Synergistic Impact of Sleep Disturbance and Social Isolation in Adult but Not Adolescent Female Mice.Journal of sleep research · 2026Article
- The Role of Worry and Emotional Intelligence in Depression in a Non-Clinical and Subclinical Sample.European journal of investigation in health, psychology and education · 2026Article
- Shared Neurocardiac Pathways Linking Atrial Fibrillation and Depression: A UK Biobank Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Clinical staging and profiling of affective disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Aging, Economic Hardship, and Depression Among Ethnic Groups in Bangladesh: A Cross-Sectional Study.Health science reports · 2026Article
- Correlates of Anxiety and Depression Among Youth in India: Findings from a Large-Scale Population-Based Cross-sectional Study.Journal of research in health sciences · 2026Article
- Persistence and Determinants of Late-Life Depression: Results of the Nationally Representative Longitudinal German Aging Survey 2008 to 2023.International journal of geriatric psychiatry · 2025Article
- Association between childhood maltreatment with subthreshold depressive symptoms and major depressive disorder in young and middle-aged adults.World journal of psychiatry · 2025Article
- The association between microaggressions and mental health among UK trans people: a cross-sectional study.Social psychiatry and psychiatric epidemiology · 2025Article
- Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus-A Mini Review.International journal of molecular sciences · 2025Review
- Influence of the COVID-19 pandemic on the prevalence of depression in U.S. adults: evidence from NHANES.Scientific reports · 2025Article
- Identifying major depressive disorder among US adults living alone using stacked ensemble machine learning algorithms.Frontiers in public health · 2025Article
- The correlation between patient health questionnaire-4 scores and major depressive disorder: a population-based study.Frontiers in public health · 2025Article
- Group arts interventions for depression and anxiety among older adults: a systematic review and meta-analysis.Nature. Mental health · 2025Article
- Diagnosis of depression based on facial multimodal data.Frontiers in psychiatry · 2025Article
- The evaluation of depression prevalence and its association with obesity phenotypes in a community-dwelling aged population.Aging clinical and experimental research · 2024Article
- Air Pollution's Hidden Toll: Links Between Ozone, Particulate Matter, and Adolescent Depression.International journal of environmental research and public health · 2024Article
- Association of cardiometabolic multimorbidity with risk of late-life depression: a nationwide twin study.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Prevalence and factors associated with depression and suicidal ideation among people with diabetes mellitus and hypertension in Uganda.African health sciences · 2024Article
1 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe occurrence of well-established risk factors for depression differs across the lifespan. Risk factors may be more strongly associated with depression at ages when occurrence, and therefore expectance, is relatively low ("on-time off-time" hypothesis). This large-scale study examined absolute and relative risks of established risk factors for depression across the lifespan.
methodsParticipants were 2,215 currently or never depressed adults aged 18 to 93 years from two cohort studies: NESDA and NESDO. The occurrence of 19 established risk factors (absolute risk) was examined in different age groups. In addition, the relative risk of these risk factors for depression was compared across age groups by examining risk factor × age interaction.
resultsThe occurrence of all risk factors differed significantly across age groups. Although most risk factors had significant associations with depression across the lifespan, for five risk factors the strength of the association was age-dependent. Stronger associations with depression in younger age were found for childhood abuse, pain, higher body mass index (BMI) and number of chronic diseases, whereas low income imposed a stronger risk in older age. Associations with depression were strongest in age groups where occurrence was lowest.
conclusionsAlthough the exposure to risk factors changes across the lifespan, the relative risk associating them to depression remains similar for most risk factors. Some specific risk factors (low income, and health factors pain, BMI, and number of chronic diseases), however, seem more strongly associated with depression in ages in which occurrence is lowest and least expected.
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