Evidence map›Paper›PMID 28528566›Full record

Trial reportMultiple sclerosis (Houndmills, Basingstoke, England)2017

Does aerobic training alleviate fatigue and improve societal participation in patients with multiple sclerosis? A randomized controlled trial.

Martin Heine, Olaf Verschuren, Erwin Lj Hoogervorst, Erik van Munster, Hub Ga Hacking, Anne Visser-Meily, Jos Wr Twisk, Heleen Beckerman, Vincent de Groot, Gert Kwakkel and 1 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Multiple sclerosis (Houndmills, Basingstoke, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Martin HeineVUmc MS Center Amsterdam and Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands/Brain Center Rudolf Magnus and Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht and Rehabilitation Center De Hoogstraat, Utrecht, The Netherlands.
Olaf VerschurenBrain Center Rudolf Magnus and Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht and Rehabilitation Center De Hoogstraat, Utrecht, The Netherlands.
Erwin Lj HoogervorstMultiple Sclerosis Center, St Antonius Hospital, Nieuwegein, The Netherlands.
Erik van MunsterDepartment of Neurology, Jeroen Bosch Ziekenhuis, Den Bosch, The Netherlands.
Hub Ga HackingMultiple Sclerosis Center, St Antonius Hospital, Nieuwegein, The Netherlands.
Anne Visser-MeilyBrain Center Rudolf Magnus and Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht and Rehabilitation Center De Hoogstraat, Utrecht, The Netherlands.
Jos Wr TwiskDepartment of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands/EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
Heleen BeckermanVUmc MS Center Amsterdam and Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands; EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
Vincent de GrootVUmc MS Center Amsterdam and Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands; EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
Gert KwakkelVUmc MS Center Amsterdam and Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands/Department of Neurorehabilitation, Reade Center of Rehabilitation and Rheumatology, Amsterdam, The Netherlands/Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
TREFAMS-ACE study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence supporting the effectiveness of aerobic training, specific for fatigue, in severely fatigued patients with multiple sclerosis (MS) is lacking.

objectiveTo estimate the effectiveness of aerobic training on MS-related fatigue and societal participation in ambulant patients with severe MS-related fatigue.

methodsPatients ( N = 90) with severe MS-related fatigue were allocated to 16-week aerobic training or control intervention. Primary outcomes were perceived fatigue (Checklist Individual Strength (CIS20r) fatigue subscale) and societal participation. An improvement of ⩾8 points on the CIS20r fatigue subscale was considered clinically relevant. Outcomes were assessed by a blinded observer at baseline, 2, 4, 6 and 12 months.

resultsOf the 89 patients that started treatment (median Expanded Disability Status Scale (interquartile range), 3.0 (2.0-3.6); mean CIS20r fatigue subscale (standard deviation (SD)), 42.6 (8.0)), 43 received aerobic training and 46 received the control intervention. A significant post-intervention between-group mean difference (MD) on the CIS20r fatigue subscale of 4.708 (95% confidence interval (CI) = 1.003-8.412; p  = 0.014) points was found in favour of aerobic training that, however, was not sustained during follow-up. No effect was found on societal participation.

conclusionAerobic training in MS patients with severe fatigue does not lead to a clinically meaningful reduction in fatigue or societal participation when compared to a low-intensity control intervention.

Indexed as

Outcome Assessment, Health CareSocial ParticipationAdultExerciseExercise TherapyFatigueFemaleHumansMaleMiddle AgedMultiple SclerosisSingle-Blind Methodexercise therapyfatigueMultiple sclerosisrandomized controlled trialrehabilitation

Identifiers

PMID28528566
PMCPMC5624301

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.