ReviewCurrent hypertension reports2017
Hypothalamic Signaling in Body Fluid Homeostasis and Hypertension.
Review in Current hypertension reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Acute effects of salt on blood pressure are mediated by serum osmolality.Journal of clinical hypertension (Greenwich, Conn.) · 2018Trial
- Acute and sub-acute toxicity assessment of tetrodotoxin in Sprague-Dawley rats following intramuscular injection.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Networked Pathological Mechanisms of Central Sympathetic Nervous System Regulation in Heart Failure and Novel Paradigms for Targeted Intervention.International journal of molecular sciences · 2026Review
- Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons.Journal of neuroendocrinology · 2025Review
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Acute hypernatremia increases functional connectivity of NaCl sensing regions in the human brain: An fMRI pilot study.Autonomic neuroscience : basic & clinical · 2024Article
- Effect of Short-Term Restraint Stress on the Hypothalamic Transcriptome Profiles of Rats with Inherited Stress-Induced Arterial Hypertension (ISIAH) and Normotensive Wistar Albino Glaxo (WAG) Rats.International journal of molecular sciences · 2024Article
- Physiological Mechanisms of Dietary Salt Sensing in the Brain, Kidney, and Gastrointestinal Tract.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Da-Chuan-Xiong Decoction Ameliorates Sodium Sensitivity and Plasma Norepinephrine via Attenuation of Brain Oxidative Stress in the DOCA-Salt Hypertensive Rats.International journal of hypertension · 2024Article
- Altered Neuronal Discharge in the Organum Vasculosum of the Lamina Terminalis Contributes to Dahl Salt-Sensitive Hypertension.Hypertension (Dallas, Tex. : 1979) · 2023Article
- The epithelial sodium channel in inflammation and blood pressure modulation.Frontiers in cardiovascular medicine · 2023Review
- Norepinephrine innervation of the supraoptic nucleus contributes to increased copeptin and dilutional hyponatremia in male rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Activation of the Organum Vasculosum of the Lamina Terminalis Produces a Sympathetically Mediated Hypertension.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Localization of the hydrogen sulfide and oxytocin systems at the depth of the sulci in a porcine model of acute subdural hematoma.Neural regeneration research · 2021Review
- Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review.International journal of molecular sciences · 2021Review
- Article
- The Bidirectional Signal Communication of Microbiota-Gut-Brain Axis in Hypertension.International journal of hypertension · 2021Review
- Neuronal Networks in Hypertension: Recent Advances.Hypertension (Dallas, Tex. : 1979) · 2020Review
- Sympathetic Nervous System Contributions to Hypertension: Updates and Therapeutic Relevance.The Canadian journal of cardiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe central nervous system plays a pivotal role in the regulation of extracellular fluid volume and consequently arterial blood pressure. Key hypothalamic regions sense and integrate neurohumoral signals to subsequently alter intake (thirst and salt appetite) and output (renal excretion via neuroendocrine and autonomic function). Here, we review recent findings that provide new insight into such mechanisms that may represent new therapeutic targets. RECENT
findingsImplementation of cutting edge neuroscience approaches such as opto- and chemogenetics highlight pivotal roles of circumventricular organs to impact body fluid homeostasis. Key signaling mechanisms within these areas include the N-terminal variant of transient receptor potential vannilloid type-1, NaX, epithelial sodium channel, brain electroneutral transporters, and non-classical actions of vasopressin. Despite the identification of several new mechanisms, future studies need to better define the neurochemical phenotype and molecular profiles of neurons within circumventricular organs for future therapeutic potential.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.