Evidence map›Paper›PMID 28528350›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017

Prevalence and impact of severe fatigue in adolescent and young adult cancer patients in comparison with population-based controls.

Hanneke Poort, Suzanne E J Kaal, Hans Knoop, Rosemarie Jansen, Judith B Prins, Eveliene Manten-Horst, Petra Servaes, Olga Husson, Winette T A van der Graaf

Erratum issued Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03476070 (Adolescent and Young Adult Cancer Patients), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03476070 unknown statusnot on this mapstarted 2018, after this paper: background citation

Adolescent and Young Adult Cancer Patients: Cognitive Toxicity on Survivorship (ACTS)

TypeobservationalSponsorNational University of SingaporeRan2018 to 2022Enrolled236ConditionsBreast Cancer, Lymphoma, Germ Cell Tumor, Cognitive Impairment
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Effects of laughter therapy on improving physical and psychological symptoms among cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  2. Pooled it
  3. Determining the feasibility of self-administered relaxing acupressure for fatigue among adolescent and young adult cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  4. Exploring young adult cancer survivors' perspectives on generative AI chatbots for symptom support.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  5. Cancer-related fatigue in cancer survivors: an updated clinical practice review for healthcare providers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Identification of distinct symptom profiles in patients with gynecologic cancers using a pre-specified symptom cluster.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Article
  20. Cancer-Related Fatigue: Causes and Current Treatment Options.Current treatment options in oncology · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hanneke PoortDepartment of Medical Psychology, Expert Center for Chronic Fatigue, Radboud University Medical Center, Nijmegen, The Netherlands. Hanneke.Poort@radboudumc.nl.
Suzanne E J KaalDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
Hans KnoopDepartment of Medical Psychology, Amsterdam Public Health research institute, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Rosemarie JansenDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
Judith B PrinsDepartment of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands.
Eveliene Manten-HorstDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
Petra ServaesDepartment of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands.
Olga HussonDepartment of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands.
Winette T A van der GraafDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe current study determined the prevalence of severe fatigue in adolescent and young adult (AYA) cancer patients (aged 18-35 years at diagnosis) consulting a multidisciplinary AYA team in comparison with gender- and age-matched population-based controls. In addition, impact of severe fatigue on quality of life and correlates of fatigue severity were examined.

methodsAYAs with cancer (n = 83) completed questionnaires including the Checklist Individual Strength (CIS-fatigue), Quality of Life (QoL)-Cancer Survivor, Hospital Anxiety and Depression Scale (reflecting psychological distress), and the Cancer Worry Scale (reflecting fear of cancer recurrence or progression).

resultsThe vast majority of participants had been treated with chemotherapy (87%) and had no active treatment at the time of participation (73.5%). Prevalence of severe fatigue (CIS-fatigue score ≥35) in AYAs with cancer (48%, n = 40/83) was significantly higher in comparison with matched population-based controls (20%, n = 49/249; p < .001). Severely fatigued AYAs with cancer reported lower QoL compared to non-severely fatigued AYAs with cancer (p < .05). Female gender, being unemployed, higher disease stage (III-IV) at diagnosis, receiving active treatment at the time of study participation, being treated with palliative intent, having had radiotherapy, higher fear of recurrence or progression, and higher psychological distress were significantly correlated with fatigue severity (p < .05).

conclusionsSevere fatigue based on a validated cut-off score was highly prevalent in this group of AYAs with cancer. QoL is significantly affected by severe fatigue, stressing the importance of detection and management of this symptom in those patients affected by a life-changing diagnosis of cancer in late adolescence or young adulthood.

Indexed as

AdolescentAdultDisease ProgressionFatigueFemaleHumansMaleNeoplasmsPrevalenceQuality of LifeSurveys and QuestionnairesSurvivorsYoung AdultAdolescent and young adultCancerFatigueQuality of life

Identifiers

PMID28528350
PMCPMC5527068

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.