Evidence map›Paper›PMID 28528301›Full record

ArticleBiomaterials2017

Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits.

Yingying Du, Haoming Liu, Qin Yang, Shuai Wang, Jianglin Wang, Jun Ma, Insup Noh, Antonios G Mikos, Shengmin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Material-Assisted Strategies for Osteochondral Defect Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Pooled it
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  12. Histological Processing of Scaffolds: Challenges and Solutions.Journal of functional biomaterials · 2025
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingying DuAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China.
Haoming LiuAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China.
Qin YangAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China.
Shuai WangAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China.
Jianglin WangAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China.
Jun MaAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China.
Insup NohDepartment of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology, Nowon-gu, Seoul 139-743, Republic of Korea.
Antonios G MikosDepartment of Bioengineering, Rice University, P.O. Box 1892, MS-142, Houston, TX 77251-1892, USA. Electronic address: mikos@rice.edu.
Shengmin ZhangAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China. Electronic address: smzhang@mail.hust.edu.cn.

Funding

In Situ Hardening Cell-Laden Constructs for Osteochondral Tissue EngineeringR01AR068073 · NIAMS · RICE UNIVERSITY · PI MIKOS, ANTONIOS G. · 2015 to 2019
$1.7M
NIAMS NIH HHS R01 AR068073
6 · The paper itself

Abstract

Osteochondral defects cannot be adequately self-repaired due to the presence of the sophisticated hierarchical structure and the lack of blood supply in cartilage. Thus, one of the major challenges remaining in this field is the structural design of a biomimetic scaffold that satisfies the specific requirements for osteochondral repair. To address this hurdle, a bio-inspired multilayer osteochondral scaffold that consisted of the poly(ε-caprolactone) (PCL) and the hydroxyapatite (HA)/PCL microspheres, was constructed via selective laser sintering (SLS) technique. The SLS-derived scaffolds exhibited an excellent biocompatibility to support cell adhesion and proliferation in vitro. The repair effect was evaluated by implanting the acellular multilayer scaffolds into osteochondral defects of a rabbit model. Our findings demonstrated that the multilayer scaffolds were able to induce articular cartilage formation by accelerating the early subchondral bone regeneration, and the newly formed tissues could well integrate with the native tissues. Consequently, the current study not only achieves osteochondral repair, but also suggests a promising strategy for the fabrication of bio-inspired multilayer scaffolds with well-designed architecture and gradient composition via SLS technique.

Indexed as

Bone RegenerationAnimalsBiocompatible MaterialsBiomimetic MaterialsCartilage, ArticularCell AdhesionCell Culture TechniquesCell LineCell ProliferationDurapatiteHumansLasersMechanical PhenomenaMesenchymal Stem CellsMicrospheresOsteogenesisBiocompatible MaterialsDurapatitepolycaprolactonePolyestersGradient microsphere scaffoldHydroxyapatiteOsteochondral defectsPoly(ε-caprolactone)Selective laser sintering

Identifiers

PMID28528301
PMCPMC5544967

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.