Evidence map›Paper›PMID 28527902›Full record

ReviewMatrix biology : journal of the International Society for Matrix Biology2017

The provisional matrix: setting the stage for tissue repair outcomes.

Thomas H Barker, Adam J Engler

Abstract readEditorialHistorical ArticleReview
In one paragraph

Review in Matrix biology : journal of the International Society for Matrix Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Science translational medicine · 2026
    Article
  5. Article
  6. Cellular and molecular regulation of fibrotic postoperative abdominal adhesions.American journal of physiology. Cell physiology · 2026
    Review
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  8. Article
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  10. Article
  11. Article
  12. Review
  13. Review
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  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Thomas H BarkerDepartment of Biomedical Engineering, School of Engineering and Applied Sciences and School of Medicine, University of Virginia, Charlottesville, VA. Electronic address: thomas.barker@virginia.edu.
Adam J EnglerDepartment of Bioengineering, Jacob School of Engineering, University of California San Diego, La Jolla, CA. Electronic address: aengler@ucsd.edu.

Funding

Mechanogenetics: An Integrated Approach to Aging in Muscle DysfunctionR01AG045428 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J · 2013 to 2022
$3.4M
Platelet-like particles for augmenting hemostasisR01HL130918 · NHLBI · UNIVERSITY OF VIRGINIA · PI BARKER, THOMAS HARRISON, LAM, WILBUR A · 2016 to 2019
$2.7M
Biomaterial Mimicry of Dynamic Matrix Stiffening During Tumor ProgressionR01CA206880 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J, YANG, JING · 2016 to 2020
$1.8M
Targeting the alpha v integrin mechanotransduction axis in IPFR01HL127283 · NHLBI · UNIVERSITY OF VIRGINIA · PI BARKER, THOMAS HARRISON · 2015 to 2018
$1.6M
NCI NIH HHS R01 CA206880NHLBI NIH HHS R01 HL127283NHLBI NIH HHS R01 HL130918NIA NIH HHS R01 AG045428
6 · The paper itself

Abstract

Since its conceptualization in the 1980s, the provisional matrix has often been characterized as a simple fibrin-containing scaffold for wound healing that supports the nascent blood clot and is functionally distinct from the basement membrane. However subsequent advances have shown that this matrix is far from passive, with distinct compositional differences as the wound matures, and providing an active role for wound remodeling. Here we review the stages of this matrix, provide an update on the state of our understanding of provisional matrix, and present some of the outstanding issues related to the provisional matrix, its components, and their assembly and use in vivo.

Indexed as

AnimalsBasement MembraneBlood PlateletsCollagenExtracellular MatrixFibrinFibroblastsFibronectinsGene ExpressionHistory, 20th CenturyHistory, 21st CenturyHumansProteoglycansSignal TransductionSkinWound HealingCollagenFibrinFibronectinsProteoglycansFibrinFibrinogenFibronectinMatrix AssemblyProteoglycansWound Healing

Identifiers

PMID28527902
PMCPMC5831186

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.