ArticleBioorganic & medicinal chemistry letters2017
Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut).
Article in Bioorganic & medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Salvianolic acid A exerts antiviral effects by targeting the S protein, a virulence factor of porcine epidemic diarrhea virus.Journal of virology · 2026Article
- Traditional Chinese medicine as a promising choice for future control of PEDV.Virus research · 2025Review
- An overview of natural herbal extracts and compounds for combating porcine epidemic diarrhea virus.Frontiers in veterinary science · 2025Review
- Potential Anti-Inflammatory Constituents fromMolecules (Basel, Switzerland) · 2024Article
- Inhibitory effect of β-escin on Zika virus infection through the interruption of viral binding, replication, and stability.Scientific reports · 2023Article
- Curative Potential of High-Value Phytochemicals on COVID-19 Infection.Biochemistry. Biokhimiia · 2023Review
- Review
- Tissue Culture Response of Ornamental and MedicinalPlants (Basel, Switzerland) · 2022Review
- Medicinal Plants with Potential Inhibitory Bioactive Compounds against Coronaviruses.Advanced pharmaceutical bulletin · 2022Review
- Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha.Frontiers in oncology · 2022Review
- Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates.Molecules (Basel, Switzerland) · 2021Review
- Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions fromMolecules (Basel, Switzerland) · 2021Article
- Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?Pharmacology & therapeutics · 2020Review
- Natural Products as Potential Leads Against Coronaviruses: Could They be Encouraging Structural Models Against SARS-CoV-2?Natural products and bioprospecting · 2020Review
- The urgent need for integrated science to fight COVID-19 pandemic and beyond.Journal of translational medicine · 2020Review
- Current Prevention of COVID-19: Natural Products and Herbal Medicine.Frontiers in pharmacology · 2020Review
- Bioactive Triterpenoid Saponins From the Seeds ofFrontiers in chemistry · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and high fatality of piglets, influencing the swine industry. Japanese horse chestnut (seed of Aesculus turbinata) contains many saponin mixtures, called escins, and has been used for a long time as a traditional medicinal plant. Structure-activity relationship (SAR) studies on escins have revealed that acylations at C-21 and C-22 with angeloyl or tigloyl groups were important for their cytotoxic effects. However, the strong cytotoxicity of escins makes them hard to utilize for other diseases and to develop as nutraceuticals. In this research, we investigated whether escin derivatives 1-7 (including new compounds 2, 3, 5 and 6), without the angeloyl or tigloyl groups and with modified glycosidic linkages by hydrolysis, have PEDV inhibitory effects with less cytotoxicity. Compounds 1-7 had no cytotoxicity at 20μM on VERO cells, while compounds 8-10 showed strong cytotoxicity at similar concentrations on PEDV. Our results suggest that escin derivatives showed strong inhibitory activities on PEDV replication with lowered cytotoxicity. These studies propose a method to utilize Japanese horse chestnut for treating PEDV and to increase the diversity of its bioactive compounds.
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