ReviewCurrent opinion in genetics & development2017
Enhancer evolution and the origins of morphological novelty.
Review in Current opinion in genetics & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- The genetic foundations of convergent traits.Nature reviews. Genetics · 2026Review
- Cis-regulatory evolution shapes facial diversity in birds and mammals.Science advances · 2026Article
- Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs.Nature neuroscience · 2026Article
- Evolution of repressive sequences within an enhancer contributed to morphological diversity in crucifer plants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Rapid and quantitative functional interrogation of human enhancer variant activity in live mice.Nature communications · 2025Article
- Memory CD4+ T cells sequentially restructure their 3D genome during stepwise activation.Frontiers in cell and developmental biology · 2025Article
- Co-option of the trichome-forming network initiated the evolution of a morphological novelty in Drosophila eugracilis.Current biology : CB · 2024Article
- Article
- CpG island turnover events predict evolutionary changes in enhancer activity.Genome biology · 2024Article
- Identification of ancestral gnathostome Gli3 enhancers with activity in mammals.Development, growth & differentiation · 2024Article
- Review
- Rapid and Quantitative Functional Interrogation of Human Enhancer Variant Activity in Live Mice.bioRxiv : the preprint server for biology · 2023Article
- Allele biased transcription factor binding across human brain regions gives mechanistic insight into eQTLs.bioRxiv : the preprint server for biology · 2023Article
- Neural crest cells as a source of microevolutionary variation.Seminars in cell & developmental biology · 2023Review
- Review
- A cis-regulatory sequence of the selector gene vestigial drives the evolution of wing scaling in Drosophila species.The Journal of experimental biology · 2023Article
- Shadow enhancers mediate trade-offs between transcriptional noise and fidelity.PLoS computational biology · 2023Article
- Resolving between novelty and homology in the rapidly evolving phallus of Drosophila.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- Leveraging massively parallel reporter assays for evolutionary questions.Genome biology · 2023Review
- Site pleiotropy of a stickleback Bmp6 enhancer.Developmental biology · 2022Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
A central goal of evolutionary biology is to understand the genetic origin of morphological novelties-i.e. anatomical structures unique to a taxonomic group. Elaboration of morphology during development depends on networks of regulatory genes that activate patterned gene expression through transcriptional enhancer regions. We summarize recent case studies and genome-wide investigations that have uncovered diverse mechanisms though which new enhancers arise. We also discuss how these enhancer-originating mechanisms have clarified the history of genetic networks underlying diversification of genital structures in flies, limbs and neural crest in chordates, and plant leaves. These studies have identified enhancers that were pivotal for morphological divergence and highlighted how novel genetic networks shaping form emerged from pre-existing ones.
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