Evidence map›Paper›PMID 28527710›Full record

ArticleThe American journal of pathology2017

CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis.

Hong Shi, Chao Zhang, Vinay Pasupuleti, Xingjian Hu, Domenick A Prosdocimo, Wenconghui Wu, Yulan Qing, Shitong Wu, Haneen Mohammad, Stanton L Gerson and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Meta-Analysis ofFrontiers in immunology · 2019
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. CCN proteins: opportunities for clinical studies-a personal perspective.Journal of cell communication and signaling · 2023
    Review
  10. Myeloid CCN3 protects against aortic valve calcification.Cell communication and signaling : CCS · 2023
    Article
  11. The role of CD36 in cardiovascular disease.Cardiovascular research · 2022
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Hong ShiDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Chao ZhangDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Vinay PasupuletiCardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Xingjian HuDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Domenick A ProsdocimoCardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Wenconghui WuCardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Yulan QingDivision of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
Shitong WuCardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Haneen MohammadCardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Stanton L GersonDivision of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
Bernard PerbalResearch Group in Law, Economics, Management, University of Nice Sophia Antipolis, Nice, France.
Philip A KlenoticCardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Nianguo DongDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: dongnianguo@hotmail.com.
Zhiyong LinCardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio. Electronic address: zhiyong.lin@case.edu.
University Hospitals of Cleveland · USUnion Hospital · CNCase Western Reserve University · USUniversité Côte d'Azur · FR

Funding

CCN3 and Aortic AneurysmR01HL117759 · NHLBI · EMORY UNIVERSITY · PI LIN, ZHIYONG · 2013 to 2017
$1.9M
KLF15 and circadian regulation of alcohol-induced liver injuryR01AA021390 · NIAAA · EMORY UNIVERSITY · PI LIN, ZHIYONG · 2014 to 2018
$1.8M
KLF2, PPARalpha and AtherothrombosisR00HL087595 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI LIN, ZHIYONG · 2010 to 2012
$747k
KLF2, PPARalpha and AtherothrombosisK99HL087595 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI LIN, ZHIYONG · 2008 to 2009
$194k
NHLBI NIH HHS K99 HL087595NHLBI NIH HHS R00 HL087595NHLBI NIH HHS R01 HL117759NIAAA NIH HHS R01 AA021390
6 · The paper itself

Abstract

Recent studies implicate the Cyr61, CTGF, Nov (CCN) matricellular signaling protein family as emerging players in vascular biology, with NOV (alias CCN3) as an important regulator of vascular homeostasis. Herein, we examined the role of CCN3 in the pathogenesis of atherosclerosis. In response to a 15-week high-fat diet feeding, CCN3-deficient mice on the atherosclerosis-prone Apoe

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAortaAtherosclerosisBone MarrowBone Marrow TransplantationCD36 AntigensCells, CulturedDiet, High-FatDisease ProgressionFoam CellsLipid MetabolismMacrophages, PeritonealMaleMice, Inbred C57BLMice, KnockoutAdaptor Proteins, Signal TransducingCcn3 protein, mouseCD36 AntigensCyfip1 protein, mouseNephroblastoma Overexpressed Protein

Identifiers

PMID28527710
PMCPMC5455065
OpenAlexW2615362272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.