ReviewCurrent opinion in chemical biology2017
Engineering genetically-encoded tools for optogenetic control of protein activity.
Review in Current opinion in chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Protein design accelerates the development and application of optogenetic tools.Computational and structural biotechnology journal · 2025Review
- Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation.Journal of visualized experiments : JoVE · 2024Article
- Expanding the Genetic Code ofACS chemical biology · 2024Article
- Time-tagged ticker tapes for intracellular recordings.Nature biotechnology · 2023Article
- Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase.ACS synthetic biology · 2022Article
- Optophysiology: Illuminating cell physiology with optogenetics.Physiological reviews · 2022Review
- Using optogenetics to link myosin patterns to contractile cell behaviors during convergent extension.Biophysical journal · 2021Article
- Photocleavable proteins that undergo fast and efficient dissociation.Chemical science · 2021Article
- Interrogating biological systems using visible-light-powered catalysis.Nature reviews. Chemistry · 2021Review
- Photoactivatable Cre knock-in mice for spatiotemporal control of genetic engineering in vivo.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation.Genome research · 2020Article
- Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity.eLife · 2020Article
- Engineering Photosensory Modules of Non-Opsin-Based Optogenetic Actuators.International journal of molecular sciences · 2020Review
- Multiplexed Photoactivation of mRNA with Single-Cell Resolution.ACS chemical biology · 2020Article
- A molecular toolbox for interrogation of membrane contact sites.The Journal of physiology · 2020Review
- A Computational Protocol for Regulating Protein Binding Reactions with a Light-Sensitive Protein Dimer.Journal of molecular biology · 2020Article
- Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent.Nucleic acids research · 2019Article
- Controlling protein conformation with light.Current opinion in structural biology · 2019Review
- Advances in optogenetic regulation of gene expression in mammalian cells using cryptochrome 2 (CRY2).Methods (San Diego, Calif.) · 2019Article
- Near-Infrared Light-Activated DNA-Agonist Nanodevice for Nongenetically and Remotely Controlled Cellular Signaling and Behaviors in Live Animals.Nano letters · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Optogenetic tools offer fast and reversible control of protein activity with subcellular spatial precision. In the past few years, remarkable progress has been made in engineering photoactivatable systems regulating the activity of cellular proteins. In this review, we discuss general strategies in designing and optimizing such optogenetic tools and highlight recent advances in the field, with specific focus on applications regulating protein catalytic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.