ArticleBrain and language2017
Longitudinal decline in speech production in Parkinson's disease spectrum disorders.
Article in Brain and language, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Systematic Review and Meta-Analyses of Word Production Abilities in Dysfunction of the Basal Ganglia: Stroke, Small Vessel Disease, Parkinson's Disease, and Huntington's Disease.Neuropsychology review · 2024Pooled it
- Progression of Cognitive Decline in Parkinson's Disease.Journal of Parkinson's disease · 2018Pooled it
- A Machine Learning Approach to Voice-Based Parkinson Disease Screening Using Multiview Spectrogram and Speech Recognition Features: Diagnostic Study.JMIR medical informatics · 2026Article
- Action and Event-Based Lexical-Semantic Processing in Parkinson's Disease.Language, cognition and neuroscience · 2026Article
- Speech Acoustic Markers Can Detect Mild Cognitive Impairment in Parkinson's Disease.IEEE journal of selected topics in signal processing · 2025Article
- Digital phenotyping of Parkinson's disease via natural language processing.NPJ Parkinson's disease · 2025Article
- Detecting neuropsychiatric fluctuations in Parkinson's Disease using patients' own words: the potential of large language models.NPJ Parkinson's disease · 2025Article
- Speech and language biomarkers for Parkinson's disease prediction, early diagnosis and progression.NPJ Parkinson's disease · 2025Review
- Unveiling the Diagnostic Potential of Linguistic Markers in Identifying Individuals with Parkinson's Disease through Artificial Intelligence: A Systematic Review.Brain sciences · 2024Review
- Narrative discourse production in Parkinson's disease: Decoupling the role of cognitive-linguistic and motor speech changes.Heliyon · 2023Article
- Predictive language comprehension in Parkinson's disease.PloS one · 2023Article
- Pausing before verb production is associated with mild cognitive impairment in Parkinson's disease.Frontiers in human neuroscience · 2023Article
- Apraxia of Speech in the Spontaneous Speech of Nonfluent/Agrammatic Primary Progressive Aphasia.Journal of Alzheimer's disease reports · 2023Article
- Longitudinal Effects of Parkinson's Disease on Speech Breathing During an Extemporaneous Connected Speech Task.Journal of speech, language, and hearing research : JSLHR · 2022Article
- Article
- Speech dysfunction, cognition, and Parkinson's disease.Progress in brain research · 2022Review
- When it is not primary progressive aphasia: A scoping review of spoken language impairment in other neurodegenerative dementias.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- The Impact of Parkinson's Disease on Breath Pauses and Their Relationship to Speech Impairment: A Longitudinal Study.American journal of speech-language pathology · 2020Article
- Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders.Neurology · 2020Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
We examined narrative speech production longitudinally in non-demented (n=15) and mildly demented (n=8) patients with Parkinson's disease spectrum disorder (PDSD), and we related increasing impairment to structural brain changes in specific language and motor regions. Patients provided semi-structured speech samples, describing a standardized picture at two time points (mean±SD interval=38±24months). The recorded speech samples were analyzed for fluency, grammar, and informativeness. PDSD patients with dementia exhibited significant decline in their speech, unrelated to changes in overall cognitive or motor functioning. Regression analysis in a subset of patients with MRI scans (n=11) revealed that impaired language performance at Time 2 was associated with reduced gray matter (GM) volume at Time 1 in regions of interest important for language functioning but not with reduced GM volume in motor brain areas. These results dissociate language and motor systems and highlight the importance of non-motor brain regions for declining language in PDSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.