Evidence map›Paper›PMID 28527056›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2017

Pathogenesis of chronic cluster headache and bouts: role of tryptamine, arginine metabolism and α

G D'Andrea, G Bussone, P Di Fiore, F Perini, A Gucciardi, A Bolner, M Aguggia, G Saracco, E Galloni, G Giordano and 1 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. The role of neurotransmitters and neuromodulators in the pathogenesis of cluster headache: a review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

G D'AndreaResearch and Innovation (R&I) s.r.l., Padua, Italy. giovidavi@virgilio.it.
G BussoneC. Besta Neurological Institute IRCCS Foundation, Milan, Italy.
P Di FioreC. Besta Neurological Institute IRCCS Foundation, Milan, Italy.
F PeriniNeurology Department, Headache Center, Vicenza Hospital, Vicenza, Italy.
A GucciardiMass Spectrometry and Metabolomic Laboratory, Institute of Pediatric Research IRP Città della Speranza, Padua, Italy.
A BolnerResearch and Innovation (R&I) s.r.l., Padua, Italy.
M AguggiaNeurology Department, Headache Center, Asti Hospital, Asti, Italy.
G SaraccoNeurology Department, Headache Center, Asti Hospital, Asti, Italy.
E GalloniNeurology Department, Headache Center, Vicenza Hospital, Vicenza, Italy.
G GiordanoWomen's and Children's Health Department, University of Padova, Padua, Italy.
A LeonResearch and Innovation (R&I) s.r.l., Padua, Italy.
Azienda Sanitaria Locale di Asti · ITInternational Renal Research Institute of Vicenza · ITCittà della Speranza Foundation · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to explore the possible role of tryptamine in the pathogenesis of chronic cluster headache along with that of adrenaline and noradrenaline (α-agonists) together with arginine metabolism in the origin of cluster bouts. Plasma levels of tyramine, tryptamine, serotonin, 5-hydroxyindolacetic acid, noradrenalin, adrenalin and the markers of arginine metabolism such as arginine, homoarginine, citrulline, ADMA and NMMA, were measured in 23 chronic cluster headache patients (10 chronic cluster ab initio and 13 transformed from episodic cluster) and 28 control subjects. The plasma levels of tyramine, tryptamine, noradrenalin and adrenalin were found several times higher in chronic cluster headache patients compared to controls, whereas the plasma levels of arginine, homoarginine and citrulline were significantly lower. No differences were found in the plasma levels of serotonin, 5-hydroxyindolacetic, ADMA and NMMA between chronic cluster headache patients and control subjects. These results provide support for a role of tryptamine in the pathogenesis of chronic cluster headache and, in particular, in the duration of the cluster bouts. In addition, the low levels of the nitric oxide substrates together with the high levels of noradrenalin and adrenalin suggest an activation of endothelial TAAR1 receptors followed by the release of nitric oxide in the circulation that may constitute the final step of the physiopathology of cluster crisis.

Indexed as

Adrenergic alpha-1 Receptor AgonistsAdultAgedAged, 80 and overArginineBiomarkersChronic DiseaseCluster HeadacheFemaleHumansMaleMiddle AgedReceptors, G-Protein-CoupledTrace Amine-Associated ReceptorsTryptaminesAdrenergic alpha-1 Receptor AgonistsArginineBiomarkersReceptors, G-Protein-CoupledTrace Amine-Associated ReceptorstryptamineTryptaminesArginine metabolismCluster headacheNoradrenalineTrace aminesTryptamine

Identifiers

PMID28527056
OpenAlexW2615701217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.