Evidence map›Paper›PMID 28526879›Full record

ArticleScientific reports2017

Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells.

Guang-Yuh Chiou, Tzu-Wei Yang, Chi-Chou Huang, Chia-Ying Tang, Jung-Yi Yen, Ming-Chang Tsai, Hsuan-Yi Chen, Nurul Fadhilah, Chun-Che Lin, Yuh-Jyh Jong

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

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  10. RNA binding proteins in cancer chemotherapeutic drug resistance.Frontiers in cell and developmental biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guang-Yuh ChiouDepartment of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Tzu-Wei YangDepartment of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Chi-Chou HuangSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Chia-Ying TangDepartment of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Jung-Yi YenDepartment of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Ming-Chang TsaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Hsuan-Yi ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Nurul FadhilahDepartment of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Chun-Che LinDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan. forest65@csmu.edu.tw.
Yuh-Jyh JongDepartment of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. yjjongnctu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancers (CRCs) are a critical health issue worldwide. Cancer stem cell (CSC) lineages are associated with tumour transformation, progression, and malignant transformation. However, how lineages are transformed and how chemoresistance is acquired by CRCs remain largely unknown. In this report, we demonstrated that the RNA-binding protein Musashi-1 enhanced the development of CD44

Indexed as

Drug Resistance, NeoplasmBiomarkersCell LineageCell Line, TumorColorectal NeoplasmsFluorescent Antibody TechniqueFluorouracilHumansImmunohistochemistryNeoplasm StagingNeoplastic Stem CellsNerve Tissue ProteinsRNA-Binding ProteinsBiomarkersFluorouracilMSI1 protein, humanNerve Tissue ProteinsRNA-Binding Proteins

Identifiers

PMID28526879
PMCPMC5438397

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.