Evidence map›Paper›PMID 28526874›Full record

ArticleScientific reports2017

Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles.

Li Tian, Patrick Lee, Burapol Singhana, Aaron Chen, Yang Qiao, Linfeng Lu, Jonathan O Martinez, Ennio Tasciotti, Adam Melancon, Steven Huang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Nano-embedded medical devices and delivery systems in interventional radiology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. In vivo imaging of radiopaque resorbable inferior vena cava filter infused with gold nanoparticles.Proceedings of SPIE--the International Society for Optical Engineering · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Li TianDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Patrick LeeCollege of Medicine, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
Burapol SinghanaDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Aaron ChenMcGovern Medical School, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Yang QiaoDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Linfeng LuDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Jonathan O MartinezCenter for Biomimetic Medicine, Houston Methodist Research Institute (HMRI), 6670 Bertner Ave., Houston, TX, 77030, USA.ORCID 0000-0002-0517-366X
Ennio TasciottiCenter for Biomimetic Medicine, Houston Methodist Research Institute (HMRI), 6670 Bertner Ave., Houston, TX, 77030, USA.ORCID 0000-0003-1187-3205
Adam MelanconDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Steven HuangDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Mitch EggersAdient Medical, Pearland, TX, 77584, USA.
Marites P MelanconDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. mmelancon@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USHouston Methodist · USAdient Medical (United States) · USSUNY Upstate Medical University · USThammasat University · THThe University of Texas Health Science Center at Houston · US

Funding

Nanoparticle- Infused Radiopaque Absorbable Medical DeviceR01HL141831 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MELANCON, MARITES PASUELO · 2018 to 2022
$1.9M
Nanoparticle-Infused Radiopaque Absorbable Medical DeviceR56HL131633 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MELANCON, MARITES PASUELO · 2016 to 2016
$405k
NHLBI NIH HHS R01 HL141831NHLBI NIH HHS R56 HL131633
6 · The paper itself

Abstract

Failure to remove a retrievable inferior vena cava (IVC) filter can cause severe complications with high treatment costs. Polydioxanone (PPDO) has been shown to be a good candidate material for resorbable IVC filters. However, PPDO is radioluscent under conventional imaging modalities. Thus, the positioning and integrity of these PPDO filters cannot be monitored by computed tomography (CT) or x-ray. Here we report the development of radiopaque PPDO IVC filters based on gold nanoparticles (AuNPs). Commercially available PPDO sutures were infused with AuNPs. Scanning electron microscopy analysis confirmed the presence of AuNP on the surface of PPDO. Micro-CT and x-ray images of the AuNP-infused PPDO sutures showed significant signal enhancement compared to untreated PPDO sutures. Elemental analysis showed that gold loading exceeded 2000 ppm. Tensile strength and in vitro cytotoxicity showed no significant difference between AuNP-infused and untreated PPDO. In a 10-week stability study, neither the gold content nor the radiopacity of the infused PPDO sutures significantly changed in the first 6 weeks. The increased attenuation of AuNP-infused PPDO sutures indicates their major advantage as a radiopaque resorbable filter material, as the radiopacity allows monitoring of the position and integrity of the filter, thereby increasing its safety and efficacy.

Indexed as

GoldMetal NanoparticlesVena Cava FiltersCell SurvivalHumansPolydioxanonePulmonary EmbolismRadiographySuturesTensile StrengthVena Cava, InferiorX-Ray MicrotomographyGoldPolydioxanone

Identifiers

PMID28526874
PMCPMC5438341
OpenAlexW2615250166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.