ArticleScientific reports2017
Aberrant functional connectivity in depression as an index of state and trait rumination.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03580967 (Vortioxetine Monotherapy for Major Depressive Disorder in Type 2 Diabetes), which is not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vortioxetine Monotherapy for Major Depressive Disorder in Type 2 Diabetes: Role of Inflammation, Kynurenine Pathway, and Structural and Functional Brain Connectivity as Biomarkers
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Meta-analytic evidence that mindfulness training alters resting state default mode network connectivity.Scientific reports · 2022Pooled it
- Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination.NeuroImage. Clinical · 2021Pooled it
- Diagnostic and Predictive Applications of Functional Near-Infrared Spectroscopy for Major Depressive Disorder: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Psychometric Properties of the Chinese Version of the Brief State Rumination Inventory.Frontiers in public health · 2022Trial
- Trial
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- Shared but distinct functional connectome profiles underlying rumination in depressed and healthy individuals.BMC psychiatry · 2025Article
- Review of Dynamic Resting-State Methods in Neuroimaging: Applications to Depression and Rumination.Human brain mapping · 2025Review
- Increased insular functional connectivity during repetitive negative thinking in major depression and healthy volunteers.Psychological medicine · 2025Article
- Reduced mind-wandering and fewer depressive symptoms associated with damage to the medial prefrontal cortex and default mode network.Neuropsychologia · 2025Article
- The chain mediation effect of rumination and worry between the intentionality and content dimensions of mind wandering and internalizing symptoms of depression and anxiety.Scientific reports · 2025Article
- Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation.Neurobiology of stress · 2025Article
- The mind wanders to dark places: Mind-wandering catalyzes rumination in the context of negative affect and impulsivity.Emotion (Washington, D.C.) · 2024Article
- Differential effects of hypnotherapy and cognitive behavioral therapy on the default mode network of depressed patients.Frontiers in psychology · 2024Article
- Connectome-based modeling reveals a resting-state functional network that mediates the relationship between social rejection and rumination.Frontiers in psychology · 2023Article
- Intrinsic Organization of Occipital Hubs Predicts Depression: A Resting-State fNIRS Study.Brain sciences · 2022Article
- Neural correlations between cognitive deficits and emotion regulation strategies: understanding emotion dysregulation in depression from the perspective of cognitive control and cognitive biases.Psychoradiology · 2022Review
- The effects of hypnotherapy compared to cognitive behavioral therapy in depression: a NIRS-study using an emotional gait paradigm.European archives of psychiatry and clinical neuroscience · 2022Article
- Disrupted Spatiotemporal Complexity of Resting-State Electroencephalogram Dynamics Is Associated With Adaptive and Maladaptive Rumination in Major Depressive Disorder.Frontiers in neuroscience · 2022Article
- The Relationship Between Default Mode and Dorsal Attention Networks Is Associated With Depressive Disorder Diagnosis and the Strength of Memory Representations Acquired Prior to the Resting State Scan.Frontiers in human neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression has been shown to be related to a variety of aberrant brain functions and structures. Particularly the investigation of alterations in functional connectivity (FC) in major depressive disorder (MDD) has been a promising endeavor, since a better understanding of pathological brain networks may foster our understanding of the disease. However, the underling mechanisms of aberrant FC in MDD are largely unclear. Using functional near-infrared spectroscopy (fNIRS) we investigated FC in the cortical parts of the default mode network (DMN) during resting-state in patients with current MDD. Additionally, we used qualitative and quantitative measures of psychological processes (e.g., state/trait rumination, mind-wandering) to investigate their contribution to differences in FC between depressed and non-depressed subjects. Our results indicate that 40% of the patients report spontaneous rumination during resting-state. Depressed subjects showed reduced FC in parts of the DMN compared to healthy controls. This finding was linked to the process of state/trait rumination. While rumination was negatively correlated with FC in the cortical parts of the DMN, mind-wandering showed positive associations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.