ArticleDevelopment (Cambridge, England)2017
A new hypothesis for foregut and heart tube formation based on differential growth and actomyosin contraction.
Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Elongation of the nascent avian foregut requires coordination of intrinsic and extrinsic cell behaviors.Developmental biology · 2025Article
- Integrating mechanical cues with engineered platforms to explore cardiopulmonary development and disease.iScience · 2023Review
- Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells.Nature biomedical engineering · 2023Article
- A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut.bioRxiv : the preprint server for biology · 2023Article
- Heart in a dish - choosing the right in vitro model.Disease models & mechanisms · 2023Article
- Quantifying endodermal strains during heart tube formation in the developing chicken embryo.Journal of biomechanics · 2023Article
- Alliance of Heart and Endoderm: Multilineage Organoids to Model Co-development.Circulation research · 2023Review
- Programming cell growth into different cluster shapes using diffusible signals.PLoS computational biology · 2021Article
- Of form and function: Early cardiac morphogenesis across classical and emerging model systems.Seminars in cell & developmental biology · 2021Review
- A Chemomechanical Model for Regulation of Contractility in the Embryonic Brain Tube.Journal Of Elasticity · 2021Article
- Capturing Cardiogenesis in Gastruloids.Cell stem cell · 2021Article
- Biomechanical Force Prediction for Lengthening of Small Intestine during Distraction Enterogenesis.Bioengineering (Basel, Switzerland) · 2020Article
- Cardiac Morphogenesis: Specification of the Four-Chambered Heart.Cold Spring Harbor perspectives in biology · 2020Review
- The Chicken as a Model Organism to Study Heart Development.Cold Spring Harbor perspectives in biology · 2020Review
- Engineering Heart Morphogenesis.Trends in biotechnology · 2020Review
- Follow Me! A Tale of Avian Heart Development with Comparisons to Mammal Heart Development.Journal of cardiovascular development and disease · 2020Review
- Biomechanical stress regulates mammalian tooth replacement via the integrin β1-RUNX2-Wnt pathway.The EMBO journal · 2020Article
- Computational simulations of the helical buckling behavior of blood vessels.International journal for numerical methods in biomedical engineering · 2019Article
- Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure.Journal of cell science · 2019Article
- Transcriptional regulation of cell shape during organ morphogenesis.The Journal of cell biology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
For decades, it was commonly thought that the bilateral heart fields in the early embryo fold directly towards the midline, where they meet and fuse to create the primitive heart tube. Recent studies have challenged this view, however, suggesting that the heart fields fold diagonally. As early foregut and heart tube morphogenesis are intimately related, this finding also raises questions concerning the traditional view of foregut formation. Here, we combine experiments on chick embryos with computational modeling to explore a new hypothesis for the physical mechanisms of heart tube and foregut formation. According to our hypothesis, differential anisotropic growth between mesoderm and endoderm drives diagonal folding. Then, active contraction along the anterior intestinal portal generates tension to elongate the foregut and heart tube. We test this hypothesis using biochemical perturbations of cell proliferation and contractility, as well as computational modeling based on nonlinear elasticity theory including growth and contraction. The present results generally support the view that differential growth and actomyosin contraction drive formation of the foregut and heart tube in the early chick embryo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.